TUBA1A and ARL3

Number of citations of the paper that reports this interaction (PMID 12417528)
20

Data Source:
HPRD (in vitro, in vivo)

		TUBA1A	ARL3
Gene Name		tubulin, alpha 1a	ADP-ribosylation factor-like 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Microtubule Cytoplasmic Microtubule Cytoplasmic Ribonucleoprotein Granule Recycling Endosome Extracellular Vesicular Exosome	Golgi Membrane Nucleus Golgi Apparatus Centrosome Spindle Microtubule Cytoplasmic Microtubule Midbody Photoreceptor Connecting Cilium Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division	Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Organelle Organization Smoothened Signaling Pathway Small GTPase Mediated Signal Transduction Protein Transport Intraciliary Transport Photoreceptor Cell Development Cilium Morphogenesis
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane L1CAM interactions G2/M Transition Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Trafficking of myristoylated proteins to the cilium Assembly of the primary cilium
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		53 interactors: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CLIP1 CNP CXCR1 CYLD DAG1 DUSP23 EGFR GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LRRK2 MAP2 MAPK6 MAPRE1 MAX MYC NFATC1 NUDT3 PAFAH1B1 PFDN1 PLA2G7 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPG20 STARD13 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	10 interactors: ARL2BP GOLGA4 LRIF1 PDE6D RP2 TLE1 TP53 TUBA1A UBR1 UNC119
Entrez ID		7846	403
HPRD ID		03959	05260
Ensembl ID		ENSG00000167552	ENSG00000138175
Uniprot IDs		Q71U36	P36405
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Communication Cell Death Death Intracellular Signal Transduction Signaling Programmed Cell Death Response To Stimulus Response To Organic Substance Positive Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Response To Stress Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Apoptotic Process Developmental Process Cell Cycle Regulation Of Intracellular Transport System Development Regulation Of Intracellular Signal Transduction Defense Response Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Organic Substance Cellular Process Negative Regulation Of Intracellular Signal Transduction Locomotion Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Immune System Process Anatomical Structure Development Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Death Immune Response-regulating Signaling Pathway Neuron Development Regulation Of Growth Nervous System Development Cell Differentiation Cell Development Regulation Of Kinase Activity Neuron Projection Morphogenesis Regulation Of Cellular Process Multicellular Organismal Development Innate Immune Response Cell Projection Morphogenesis Cell Migration	Positive Regulation Of Peptidyl-tyrosine Phosphorylation Visual Perception Sensory Perception Of Light Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Clathrin-mediated Endocytosis Regulation Of Cellular Amino Acid Metabolic Process Protein Localization Post-Golgi Vesicle-mediated Transport Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Protein Localization To Organelle Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Notch Signaling Pathway Regulation Of Catalytic Activity Cellular Localization Protein Transport Protein Localization To Nucleus Establishment Of Protein Localization Mitotic Cell Cycle Process Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Intracellular Transport Mitochondrial DNA Repair Response To Leucine Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Phosphorylation Mitotic Cell Cycle Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Mitotic Cytokinetic Process Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Sensory Perception Regulation Of Intracellular Signal Transduction ER Overload Response Positive Regulation Of Phosphorylation Negative Regulation Of Macroautophagy Stress-induced Premature Senescence
Tagcloud ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread	accord brucei congolense conservation cruzi donovani eukaryotes flanking genesis leishmania monophyly multigene organization parasites phylogeny primitive protozoan rab1 reconstitution representatives s12 salivarian transporter trypanosoma trypanosomatids trypanosomes unicellular vivax ypt6
Tagcloud (Difference) ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace tubulin verified widespread	accord brucei congolense conservation cruzi donovani eukaryotes flanking genesis leishmania monophyly multigene organization parasites phylogeny primitive protozoan rab1 reconstitution representatives s12 salivarian trypanosoma trypanosomatids trypanosomes unicellular vivax ypt6
Tagcloud (Intersection) ?		transporter