ZAP70 and SLA2

Number of citations of the paper that reports this interaction (PMID 11891219)
6

Data Source:
HPRD (in vivo)

		ZAP70	SLA2
Gene Name		zeta-chain (TCR) associated protein kinase 70kDa	Src-like-adaptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Cytoplasm Late Endosome Plasma Membrane Endosome Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	SH3/SH2 Adaptor Activity Protein Binding Protein N-terminus Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Signal Transduction B Cell Mediated Immunity Intracellular Receptor Signaling Pathway T Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of B Cell Activation
Pathways		TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System
Drugs		Staurosporine
Diseases
GWAS
Protein-Protein Interactions		58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1	6 interactors: CBL CD247 CSF1 ERBB2 LAMC2 ZAP70
Entrez ID		7535	84174
HPRD ID		01495	05955
Ensembl ID		ENSG00000115085	ENSG00000101082
Uniprot IDs		P43403	Q9H6Q3
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation	Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Mammary Gland Fat Development T Cell Receptor Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Beta Selection Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Osteoclast Proliferation Positive Regulation Of Cell Proliferation Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Immature T Cell Proliferation In Thymus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Monocyte Differentiation Mammary Duct Terminal End Bud Growth Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Growth Positive Regulation Of Cell-cell Adhesion Monocyte Activation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Activation
Tagcloud ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	adjacent already bases blh1 cerevisiae correspond cosmid displays dnaj finger frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced similarity sin4 ure2 xiv zinc zwf1
Tagcloud (Difference) ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	adjacent already bases blh1 cerevisiae correspond cosmid displays dnaj finger frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced similarity sin4 ure2 xiv zinc zwf1
Tagcloud (Intersection) ?