TUBA1A and PLA2G7

Number of citations: 54 (PubMedID 9384577)
Data Source: HPRD (in vivo, in vitro)

		TUBA1A	PLA2G7
Name		tubulin alpha 1a	phospholipase A2 group VII
Structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Motile Cilium Neuromuscular Junction Sperm Flagellum Cytoplasmic Ribonucleoprotein Granule Cell Projection Synapse Recycling Endosome Extracellular Exosome	Extracellular Region Extracellular Space Low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Phospholipid Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Calcium-independent Phospholipase A2 Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Startle Response Intracellular Protein Transport Microtubule-based Process Centrosome Cycle Smoothened Signaling Pathway Memory Locomotory Behavior Adult Locomotory Behavior Visual Learning Response To Mechanical Stimulus Glial Cell Differentiation Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Hippocampus Development Pyramidal Neuron Differentiation Cerebral Cortex Development Neurogenesis Neuron Differentiation Flagellated Sperm Motility Adult Behavior Cytoskeleton-dependent Intracellular Transport Response To Tumor Necrosis Factor Locomotory Exploration Behavior Microtubule Polymerization Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Synapse Organization Cell Division Neuron Apoptotic Process Motor Behavior Cellular Response To Calcium Ion Organelle Transport Along Microtubule Neuron Projection Arborization Response To L-glutamate	Lipid Metabolic Process Phospholipid Catabolic Process Lipid Catabolic Process Peptide Hormone Processing Low-density Lipoprotein Particle Remodeling Lipid Oxidation Plasma Lipoprotein Particle Oxidation Phosphatidylcholine Catabolic Process Platelet Activating Factor Metabolic Process Positive Regulation Of Inflammatory Response Platelet Activating Factor Catabolic Process Positive Regulation Of Monocyte Chemotaxis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling	Synthesis, secretion, and deacylation of Ghrelin
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine	Rilapladib (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Composite immunoglobulin trait (IgG/IgM) ( 28628107 )	Blood protein levels ( 30072576 ) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643 ) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 22003152 23118302 ) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643 )
Novel Interactors		3 novel interactors: ACVR1B AMHR2 TUBA1C	None recorded
Interacting Genes		66 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EIF4ENIF1 EML1 ENO1 GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 OGT PAFAH1B1 PGK1 PLA2G7 PLK2 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK SYTL4 TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	1 interacting genes: TUBA1A
Entrez ID		7846	7941
HPRD ID		03959	03407
Ensembl ID		ENSG00000167552	ENSG00000146070
Uniprot IDs		Q71U36	Q13093
PDB IDs		5JCO 6J8F 6WSL 7C1M 7UN1 7UNG 8J07 8SH7	3D59 3D5E 3F96 3F97 3F98 3F9C 5I8P 5I9I 5JAD 5JAH 5JAL 5JAN 5JAO 5JAP 5JAR 5JAS 5JAT 5JAU 5LP1 5LYY 5LZ2 5LZ4 5LZ5 5LZ7 5LZ8 5LZ9 5YE7 5YE8 5YE9 5YEA 6M06 6M07 6M08
GO Terms Enriched among Interactors		Cytoplasm Cytosol Regulation Of Cell Growth Intracellular Signaling Cassette Microtubule Binding Regulation Of Growth Microtubule Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein-containing Complex Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cytoskeleton Positive Regulation Of Cell Communication Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Signaling Protein Metabolic Process Regulation Of Developmental Process Regulation Of Intrinsic Apoptotic Signaling Pathway Myeloid Leukocyte Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Cell Migration Neutrophil Chemotaxis Developmental Process Cytoplasmic Microtubule Microtubule-based Process Ubiquitin Protein Ligase Binding Catabolic Process Leukocyte Migration Protein Serine/threonine Kinase Activity Protein Kinase Activity Tubulin Binding Negative Regulation Of Cell Growth Cytoskeleton Organization Neutrophil Migration Protein Localization To Nucleus Cellular Developmental Process Microtubule Cytoskeleton Microtubule Positive Regulation Of Apoptotic Process Leukocyte Aggregation Regulation Of Microtubule-based Process	Pyramidal Neuron Differentiation Cerebellar Cortex Morphogenesis Condensed Chromosome Neuron Projection Arborization Locomotory Exploration Behavior Motor Behavior Response To L-glutamate Axonemal Microtubule Exploration Behavior Dentate Gyrus Development Forebrain Morphogenesis Microtubule Polymerization Or Depolymerization Homeostasis Of Number Of Cells Within A Tissue Microtubule Polymerization Startle Response Visual Behavior Sperm Flagellum Visual Learning Response To Amino Acid Glial Cell Differentiation Flagellated Sperm Motility Smoothened Signaling Pathway Cytoplasmic Microtubule Cerebral Cortex Development Centrosome Cycle Recycling Endosome Central Nervous System Neuron Differentiation Response To Tumor Necrosis Factor Cytoplasmic Ribonucleoprotein Granule Adult Locomotory Behavior Hippocampus Development Neuron Apoptotic Process Structural Constituent Of Cytoskeleton Microtubule Organizing Center Organization Cilium Movement Involved In Cell Motility Neurogenesis Protein Polymerization Response To Calcium Ion Neuromuscular Junction Memory Associative Learning Mitotic Cell Cycle Neuromuscular Process Sperm Motility Organelle Transport Along Microtubule Cellular Response To Calcium Ion Cilium-dependent Cell Motility Neuron Migration Adult Behavior Learning