ZAP70 and DUSP3

Number of citations of the paper that reports this interaction (PubMedID 12447358)
0

Data Source:
HPRD (in vivo)

		ZAP70	DUSP3
Description		zeta chain of T cell receptor associated protein kinase 70	dual specificity phosphatase 3
Image
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Membrane Raft	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity Protein Kinase Binding Receptor Signaling Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding MAP Kinase Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	Adaptive Immune Response Immune System Process Protein Phosphorylation Immune Response Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration T Cell Aggregation T Cell Migration	Negative Regulation Of Signal Transduction Dephosphorylation Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Chemotaxis Regulation Of Focal Adhesion Assembly Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Focal Adhesion Disassembly
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules RHOH GTPase cycle Nuclear events stimulated by ALK signaling in cancer	ERKs are inactivated
Drugs		Staurosporine Fostamatinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Fractures ( 30158200) HDL cholesterol ( 25961943 27036123) High density lipoprotein cholesterol levels ( 33339817) Metabolite levels ( 23823483) Triglycerides ( 25961943)
Interacting Genes		67 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PELI1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	15 interacting genes: APP BNIP3L CASK EGF EGFR FGF7 MAP2K2 MAPK1 MAPK3 MEOX1 NEUROD1 PDGFA STAT1 SYK ZAP70
Entrez ID		7535	1845
HPRD ID		01495	02553
Ensembl ID		ENSG00000115085	ENSG00000108861
Uniprot IDs		P43403	P51452
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76 7SIY	1J4X 1VHR 3F81 8TK2 8TK3 8TK4 8TK5 8TK6 9DJ9
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Signal Transduction Regulation Of Lymphocyte Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Immune System Process Lymphocyte Activation Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune System Process Regulation Of T Cell Activation Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction T Cell Activation Intracellular Signal Transduction Activation Of Immune Response Plasma Membrane Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Membrane Raft Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Leukocyte Proliferation Regulation Of T Cell Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction SH3 Domain Binding Negative Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Lymphocyte Proliferation Positive Regulation Of Multicellular Organismal Process Mononuclear Cell Proliferation	Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Golgi Inheritance Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Trachea Formation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Protein Kinase Activity Positive Regulation Of Protein Metabolic Process ERK1 And ERK2 Cascade Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Vesicle-mediated Transport Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Glial Cell Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Epithelial Cell Proliferation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Golgi Organization
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