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ZAP70 and WIPF1
Number of citations of the paper that reports this interaction (PMID
12504004
)
47
Data Source:
HPRD
(in vivo)
ZAP70
WIPF1
Gene Name
zeta-chain (TCR) associated protein kinase 70kDa
WAS/WASL interacting protein family, member 1
Image
Gene Ontology Annotations
Cellular Component
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
T Cell Receptor Complex
Membrane Raft
Ruffle
Cytosol
Actin Filament
Actin Cytoskeleton
Cytoplasmic Membrane-bounded Vesicle
Molecular Function
Phosphotyrosine Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Actin Binding
Protein Binding
Profilin Binding
Biological Process
Adaptive Immune Response
Protein Phosphorylation
Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Migration
Peptidyl-tyrosine Phosphorylation
T Cell Differentiation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
T Cell Activation
B Cell Activation
Beta Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Innate Immune Response
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
T Cell Aggregation
T Cell Migration
Protein Complex Assembly
Actin Polymerization Or Depolymerization
Actin Filament-based Movement
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Innate Immune Response
Response To Other Organism
Pathways
TCR signaling
Generation of second messenger molecules
Translocation of ZAP-70 to Immunological synapse
Adaptive Immune System
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Drugs
Staurosporine
Diseases
GWAS
Protein-Protein Interactions
58 interactors:
ABL1
ACP1
ANAPC11
APP
ASB3
CARD11
CBL
CBLB
CBLC
CD247
CD3E
CD5
CD79B
CRK
CSK
DBNL
DEF6
DUSP3
EGFR
ERBB3
FCGR3A
FCRL3
FYN
GAB2
GRB2
IFNAR1
LAT
LAX1
LCK
LCP2
MUC1
NDUFB8
NFAM1
NR0B2
PAG1
PLCG1
PRLR
PTK2B
PTPN22
PTPN3
PTPN6
PTPRC
RASA1
SH2B3
SH3BP2
SHB
SHC1
SIT1
SLA
SLA2
SLAMF6
SOS1
TUBA1A
TUBA4A
TUBB
TYROBP
VAV1
WIPF1
22 interactors:
ABI2
ACTC1
ACTG1
ALAS1
APBB1
CDC42
CRKL
CTTN
FASTK
GRB2
HCK
HOMER3
ITSN2
NCK1
PRKCQ
PRPF40A
SEC24C
WAS
WASL
WBP4
WWP2
ZAP70
Entrez ID
7535
7456
HPRD ID
01495
03835
Ensembl ID
ENSG00000115085
ENSG00000115935
Uniprot IDs
P43403
O43516
Q2YDC4
PDB IDs
1FBV
1M61
1U59
2CBL
2OQ1
2OZO
2Y1N
3ZNI
4A4B
4A4C
4K2R
2A41
Enriched GO Terms of Interacting Partners
?
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Immune System Process
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Cell Activation
Positive Regulation Of Immune System Process
Innate Immune Response
Immune Response
Positive Regulation Of Immune Response
Signal Transduction
Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Regulation Of Cell Activation
Defense Response
Fc Receptor Signaling Pathway
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Regulation Of Signaling
Regulation Of T Cell Activation
Cell Communication
Regulation Of Cell-cell Adhesion
Cellular Response To Stimulus
Positive Regulation Of Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
ERBB Signaling Pathway
Response To Stimulus
Leukocyte Activation
T Cell Receptor Signaling Pathway
Intracellular Signal Transduction
Lymphocyte Activation
Platelet Activation
Blood Coagulation
Regulation Of Intracellular Signal Transduction
Hemostasis
T Cell Costimulation
Fc-epsilon Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Homotypic Cell-cell Adhesion
Response To Stress
Wound Healing
Single Organismal Cell-cell Adhesion
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Movement Of Cell Or Subcellular Component
Locomotion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Immune Response
Phagocytosis
Endocytosis
Actin Filament Organization
Regulation Of Cytoskeleton Organization
Innate Immune Response
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Neuron Projection Development
Regulation Of Actin Cytoskeleton Organization
Cell Migration
Actin Cytoskeleton Organization
Positive Regulation Of Actin Nucleation
Regulation Of Immune Response
Axon Guidance
Cell Motility
Positive Regulation Of Immune System Process
Positive Regulation Of Organelle Organization
Actin Filament-based Process
Regulation Of Actin Filament-based Process
Neuron Projection Morphogenesis
Neuron Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Vesicle-mediated Transport
Cytoskeleton Organization
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Cellular Component Organization
Neuron Differentiation
Axonogenesis
Cell Projection Organization
Cell Projection Morphogenesis
Axon Development
Cell Part Morphogenesis
Actin Polymerization Or Depolymerization
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Organelle Organization
Immune System Process
Immune Response
Tagcloud
?
cd3
coimmunoprecipitated
compartment
cytosol
detergent
failing
grb2
hsos1
insoluble
jurkat
localize
nonidet
p145
p21ras
p36
p95
participates
particulate
phospholipase
phosphoprotein
plc
redistributed
shc
tcr
vav
vicinity
zeta
Tagcloud (Difference)
?
cd3
coimmunoprecipitated
compartment
cytosol
detergent
failing
grb2
hsos1
insoluble
jurkat
localize
nonidet
p145
p21ras
p36
p95
participates
particulate
phospholipase
phosphoprotein
plc
redistributed
shc
tcr
vav
vicinity
zeta
Tagcloud (Intersection)
?