ZAP70 and PTPN22

Number of citations of the paper that reports this interaction (PMID 16461343)
57

Data Source:
HPRD (in vivo)

		ZAP70	PTPN22
Gene Name		zeta-chain (TCR) associated protein kinase 70kDa	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Nucleus Cytoplasm Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Kinase Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Protein Dephosphorylation T Cell Differentiation Regulation Of Natural Killer Cell Proliferation Peptidyl-tyrosine Dephosphorylation Phosphoanandamide Dephosphorylation Regulation Of Innate Immune Response Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation
Pathways		TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System
Drugs		Staurosporine
Diseases
GWAS			Breast cancer ( 23535729) Crohn's disease ( 18587394 21102463 23128233) Hypothyroidism ( 22493691) Myasthenia gravis ( 23055271) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 17804836 18794853 17554300 20453842 19503088) Type 1 diabetes ( 17632545 19430480 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)
Protein-Protein Interactions		58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1	9 interactors: CBL CD247 CD3E CSK GRB2 LCK PRKCD VAV1 ZAP70
Entrez ID		7535	26191
HPRD ID		01495	06100
Ensembl ID		ENSG00000115085	ENSG00000134242
Uniprot IDs		P43403	B4DZW8 Q9Y2R2
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation	Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Cell Activation Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Innate Immune Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune System Process Immune Response Defense Response Lymphocyte Activation Blood Coagulation Hemostasis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Leukocyte Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration
Tagcloud ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	aitd antigens autoimmunity breakdown cd28 cd40 ctla4 develops discrepancy fcrl3 happen hashimoto humoral hyperthyroidism hypothyroidism il2ra immunogenicity immunoregulatory infiltrating insults iodine multifactorial parity preponderance thymus thyroglobulin thyroid thyrotropin wrong
Tagcloud (Difference) ?		cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta	aitd antigens autoimmunity breakdown cd28 cd40 ctla4 develops discrepancy fcrl3 happen hashimoto humoral hyperthyroidism hypothyroidism il2ra immunogenicity immunoregulatory infiltrating insults iodine multifactorial parity preponderance thymus thyroglobulin thyroid thyrotropin wrong
Tagcloud (Intersection) ?