ZAP70 and PELI1

Number of citations of the paper that reports this interaction (PubMedID 35058288)
0

Data Source:
BioGRID (pull down)

		ZAP70	PELI1
Description		zeta chain of T cell receptor associated protein kinase 70	pellino E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Membrane Raft	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Immune System Process Protein Phosphorylation Immune Response Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration T Cell Aggregation T Cell Migration	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cytokine Production DNA Repair DNA Damage Response Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TORC1 Signaling T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of T Cell Activation Positive Regulation Of B Cell Activation Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules RHOH GTPase cycle Nuclear events stimulated by ALK signaling in cancer	Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs		Staurosporine Fostamatinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)
Interacting Genes		67 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PELI1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	33 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB EGFR GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK3 SQSTM1 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14 ZAP70
Entrez ID		7535	57162
HPRD ID		01495	17834
Ensembl ID		ENSG00000115085	ENSG00000197329
Uniprot IDs		P43403	Q53T26 Q96FA3
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76 7SIY	9IF9
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Signal Transduction Regulation Of Lymphocyte Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Immune System Process Lymphocyte Activation Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune System Process Regulation Of T Cell Activation Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction T Cell Activation Intracellular Signal Transduction Activation Of Immune Response Plasma Membrane Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Membrane Raft Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Leukocyte Proliferation Regulation Of T Cell Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction SH3 Domain Binding Negative Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Lymphocyte Proliferation Positive Regulation Of Multicellular Organismal Process Mononuclear Cell Proliferation	Intracellular Signal Transduction ATP Binding Non-canonical NF-kappaB Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Regulation Of Intracellular Signal Transduction Nucleotide Binding Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cytosol Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Transferase Activity Interleukin-1-mediated Signaling Pathway Toll Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Polyubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Protein-containing Complex Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Cell Surface Toll-like Receptor Signaling Pathway Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Toll-like Receptor Signaling Pathway Post-translational Protein Modification Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Protein Serine Kinase Activity Immune Response-activating Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Cellular Response To Hypoxia Nucleus
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