TUBA1A and PAFAH1B1

Number of citations of the paper that reports this interaction (PMID 9384577)
41

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		TUBA1A	PAFAH1B1
Gene Name		tubulin, alpha 1a	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Microtubule Cytoplasmic Microtubule Cytoplasmic Ribonucleoprotein Granule Recycling Endosome Extracellular Vesicular Exosome	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cell Cortex Axon Growth Cone Cell Leading Edge Motile Primary Cilium Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Protein Homodimerization Activity Phospholipase Binding Dynein Binding Dynein Intermediate Chain Binding Phosphoprotein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Organelle Organization Microtubule-based Process Mitotic Nuclear Division Nuclear Migration Synaptic Transmission Neuroblast Proliferation Learning Or Memory Retrograde Axon Cargo Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Regulation Of Rho GTPase Activity Osteoclast Development Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Nuclear Envelope Disassembly Establishment Of Centrosome Localization
Pathways		Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane L1CAM interactions G2/M Transition Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System	Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs		Albendazole Vinblastine Mebendazole Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CLIP1 CNP CXCR1 CYLD DAG1 DUSP23 EGFR GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LRRK2 MAP2 MAPK6 MAPRE1 MAX MYC NFATC1 NUDT3 PAFAH1B1 PFDN1 PLA2G7 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPG20 STARD13 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70	22 interactors: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DISC1 DNAI1 HSPH1 KARS KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		7846	5048
HPRD ID		03959	03329
Ensembl ID		ENSG00000167552	ENSG00000007168
Uniprot IDs		Q71U36	P43034
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Communication Cell Death Death Intracellular Signal Transduction Signaling Programmed Cell Death Response To Stimulus Response To Organic Substance Positive Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Response To Stress Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Apoptotic Process Developmental Process Cell Cycle Regulation Of Intracellular Transport System Development Regulation Of Intracellular Signal Transduction Defense Response Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Organic Substance Cellular Process Negative Regulation Of Intracellular Signal Transduction Locomotion Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Immune System Process Anatomical Structure Development Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Death Immune Response-regulating Signaling Pathway Neuron Development Regulation Of Growth Nervous System Development Cell Differentiation Cell Development Regulation Of Kinase Activity Neuron Projection Morphogenesis Regulation Of Cellular Process Multicellular Organismal Development Innate Immune Response Cell Projection Morphogenesis Cell Migration	Microtubule-based Process Microtubule Cytoskeleton Organization Mitotic Cell Cycle Process Mitotic Nuclear Division Mitotic Cell Cycle Nervous System Development Neuron Migration Cell Cycle Process Movement Of Cell Or Subcellular Component Cytoskeleton Organization Regulation Of Neuron Projection Development Generation Of Neurons Organelle Localization Neurogenesis Microtubule Bundle Formation Cytoskeleton-dependent Intracellular Transport Cell Cycle Multicellular Organismal Development Regulation Of Cell Projection Organization System Development Establishment Of Organelle Localization Regulation Of Neuron Differentiation Organelle Organization Developmental Process Central Nervous System Development Anatomical Structure Development Regulation Of Neurogenesis Cellular Localization Brain Development G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Cell Projection Organization Head Development Cell Migration Microtubule-based Movement Regulation Of Cell Development Dendrite Development Locomotion Establishment Of Chromosome Localization Cell Motility Cell Differentiation Cerebral Cortex Development Organelle Transport Along Microtubule Neuron Projection Extension Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Establishment Of Vesicle Localization Mitotic Centrosome Separation Microtubule Severing
Tagcloud ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive lis1 lissencephaly migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Difference) ?		brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread	acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive lis1 lissencephaly migration neuronal null olfactory participates phenotypes soon thought understand
Tagcloud (Intersection) ?