ZYX and ACTN1

Number of citations of the paper that reports this interaction (PMID 10224105)
14

Data Source:
HPRD (in vivo, in vitro)

		ZYX	ACTN1
Gene Name		zyxin	actinin, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Adherens Junction Focal Adhesion	Stress Fiber Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Fascia Adherens Focal Adhesion Z Disc Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Poly(A) RNA Binding	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Ion Channel Binding Actin Filament Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Viral Process Stress Fiber Assembly Regulation Of Inflammatory Response	Platelet Degranulation Blood Coagulation Platelet Activation Extracellular Matrix Organization Cell Junction Assembly Regulation Of Apoptotic Process Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Crosslink Formation Regulation Of Nucleic Acid-templated Transcription
Pathways			Cell junction organization Syndecan interactions Response to elevated platelet cytosolic Ca2+ Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Nephrin interactions Platelet degranulation Non-integrin membrane-ECM interactions Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Smoking behavior ( 19247474)
Protein-Protein Interactions		27 interactors: ACTN1 ATXN1 BSPRY ENAH HIPK3 IMP3 LASP1 LATS1 LIN7A NEBL NEDD9 OPRM1 PDLIM5 PHF21A RABEPK RGS2 RPH3AL RTN4IP1 SREBF2 TES VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384	70 interactors: ACTN3 ADORA2A APC ATXN2 ATXN7 CACNA1A CAMK2A CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 EPM2AIP1 ERBB2IP FBP1 FXN GFI1B GIPC1 GIT2 GRIA4 GRIN2A GTF2H1 ITGB1 KAT2B KCTD6 KPNA2 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SLC2A4 SORBS2 SPERT SRC SSX2IP TES TTN VCL XRCC4 ZYX
Entrez ID		7791	87
HPRD ID		03592	00020
Ensembl ID		ENSG00000159840	ENSG00000072110
Uniprot IDs		Q15942 Q96AF9	P12814
PDB IDs			2EYI 2EYN
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of CAMP-mediated Signaling Negative Regulation Of Transferase Activity Integrin-mediated Signaling Pathway Negative Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Actin Cytoskeleton Organization Wound Healing Negative Regulation Of Protein Serine/threonine Kinase Activity Antigen Receptor-mediated Signaling Pathway Exocytosis Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Wounding Negative Regulation Of Transport Negative Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of Cellular Process Platelet Activation Negative Regulation Of Wnt Protein Secretion Cardiac Muscle Thin Filament Assembly Peptidyl-threonine Phosphorylation Negative Regulation Of Signaling Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Immune Response-regulating Signaling Pathway Neutrophil Chemotaxis Negative Regulation Of Cellular Protein Metabolic Process Neutrophil Migration Regulation Of Signal Transduction Positive Regulation Of Rac GTPase Activity Cell Differentiation Granulocyte Chemotaxis Secretion By Cell Regulation Of Immune Response Developmental Process Actin Filament Bundle Assembly Negative Regulation Of Protein Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process	Cytoskeleton Organization Cell Adhesion Cellular Component Assembly Organelle Organization Cell Development Regulation Of Protein Kinase Activity Actin Filament-based Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Cell-substrate Adhesion Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorus Metabolic Process Cell Differentiation Generation Of Neurons Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Stress Actomyosin Structure Organization Neuron Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Central Nervous System Development Positive Regulation Of Transferase Activity Regulation Of Signaling Response To Stimulus Response To Wounding Regulation Of Phosphorylation Cell-cell Junction Organization Regulation Of Cell Projection Organization Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Single Organismal Cell-cell Adhesion Adherens Junction Organization Neuron Projection Development Neuron Differentiation Anatomical Structure Development Blood Coagulation Cell Surface Receptor Signaling Pathway Cell Projection Organization Hemostasis Cell-matrix Adhesion Apical Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Neuron Projection Development
Tagcloud ?		ajuba apical branch dachs dco distinctive epistasis extend fat fundamental hippo incomplete intercellular jub lim localizes mechanical myosin oncogenesis overlap overlaps peaks raises share vertices ways yorkie zyx102 zyxin	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?		ajuba apical branch dachs dco distinctive epistasis extend fat fundamental hippo incomplete intercellular jub lim localizes mechanical myosin oncogenesis overlap overlaps peaks raises share vertices ways yorkie zyx102 zyxin	b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plec plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?