ZYX and NME5

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		ZYX	NME5
Description		zyxin	NME/NM23 family member 5
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle Anchoring Junction	Radial Spoke Extracellular Region Cytoplasm Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection 9+2 Motile Cilium
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding	Nucleoside Diphosphate Kinase Activity Protein Binding 3'-5'-DNA Exonuclease Activity Hydrolase Activity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Cellular Response To Type II Interferon	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Spermatogenesis Spermatid Development Nucleoside Metabolic Process Ventricular System Development Cell Differentiation Spermatid Differentiation Establishment Of Localization In Cell Cilium Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs		Artenimol
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)	Atrial fibrillation ( 29892015) Autism spectrum disorder or schizophrenia ( 28540026) Carboplatin disposition in epthelial ovarian cancer ( 29367611)
Interacting Genes		36 interacting genes: ACTN1 ATXN1 BSPRY CASS4 CEBPA ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B	4 interacting genes: CEP76 DYDC1 DYDC2 ZYX
Entrez ID		7791	8382
HPRD ID		03592	04655
Ensembl ID		ENSG00000159840	ENSG00000112981
Uniprot IDs		Q15942 Q96AF9	A0A0S2Z4L9 P56597
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		Focal Adhesion Profilin Binding Anchoring Junction Actin Filament Organization Actin Binding Postsynapse Regulation Of Cellular Component Size Cytoplasm Stress Fiber Supramolecular Fiber Organization Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Protein Tyrosine Kinase Activity Actin Polymerization Or Depolymerization Platelet Activation Cytoskeletal Protein Binding Cytoskeleton Lamellipodium Regulation Of Cell Size	Set1C/COMPASS Complex
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