ZYX and PHF21A

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		ZYX	PHF21A
Description		zyxin	PHD finger protein 21A
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle Anchoring Junction	Histone Deacetylase Complex Nucleus Nucleoplasm DNA Repair Complex
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Cellular Response To Type II Interferon	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization
Pathways			HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs		Artenimol
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)	Adult body size ( 32376654) Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Axial length ( 24144296) Height ( 29782485) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Menarche (age at onset) ( 21102462 25231870) Mild age-related type 2 diabetes ( 34737425) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		36 interacting genes: ACTN1 ATXN1 BSPRY CASS4 CEBPA ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B	16 interacting genes: BANP EXOSC8 FHL2 FHL3 H3C14 HDAC1 HDAC2 HMG20B KDM1A KRT40 L3MBTL3 LPXN RCOR1 SP3 TRAF1 ZYX
Entrez ID		7791	51317
HPRD ID		03592	10516
Ensembl ID		ENSG00000159840	ENSG00000135365
Uniprot IDs		Q15942 Q96AF9	Q96BD5
PDB IDs			2PUY 2YQL
Enriched GO Terms of Interacting Partners?		Focal Adhesion Profilin Binding Anchoring Junction Actin Filament Organization Actin Binding Postsynapse Regulation Of Cellular Component Size Cytoplasm Stress Fiber Supramolecular Fiber Organization Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Protein Tyrosine Kinase Activity Actin Polymerization Or Depolymerization Platelet Activation Cytoskeletal Protein Binding Cytoskeleton Lamellipodium Regulation Of Cell Size	Chromatin Binding Chromatin Organization Protein Lysine Delactylase Activity Fungiform Papilla Formation Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Hair Follicle Placode Formation Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Promoter-specific Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Lysine Deacetylase Activity Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides DNA Repair Complex Cell Differentiation NuRD Complex Nucleoplasm Histone Deacetylase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Regulation Of Cell Fate Specification Regulation Of Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Histone Methyltransferase Complex Granulocyte Differentiation Cellular Developmental Process NF-kappaB Binding Enzyme Binding Regulation Of Androgen Receptor Signaling Pathway Focal Adhesion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation
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