ZYX and RPH3AL

Number of citations: 0 (PubMedID 9367993)
Data Source: HPRD (two hybrid, in vivo)

		ZYX	RPH3AL
Name		zyxin	rabphilin 3A like (without C2 domains)
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle Anchoring Junction	Cytoplasm Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Presynapse
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding	Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Cellular Response To Type II Interferon	Intracellular Protein Transport Exocytosis G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Secretion Glucose Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion
Drugs		Artenimol	None
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) White blood cell count (basophil) ( 27863252 )	AIDS progression ( 21502085 ) DHEAS levels ( 34748635 ) Dimensional psychopathology (Cognitive) ( 29496196 ) Idiopathic intracranial hypertension ( 29608535 ) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001 )
Interacting Genes		36 interacting genes: ACTN1 ATXN1 BSPRY CASS4 CEBPA ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B	26 interacting genes: AIRIM ANKRD11 ATPAF2 HNRNPK KHDRBS3 MID2 MYO15B PNMA3 PRKAB2 PSME3 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 RSPH14 SAAL1 SCNM1 SNCA TCEA3 UNC13B ZYX
Entrez ID		7791	9501
HPRD ID		03592	05345
Ensembl ID		ENSG00000159840	ENSG00000181031
Uniprot IDs		Q15942 Q96AF9	A8K7D5 Q9UNE2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Focal Adhesion Profilin Binding Anchoring Junction Actin Filament Organization Actin Binding Postsynapse Regulation Of Cellular Component Size Cytoplasm Stress Fiber Supramolecular Fiber Organization Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Protein Tyrosine Kinase Activity Actin Polymerization Or Depolymerization Platelet Activation Cytoskeletal Protein Binding Cytoskeleton Lamellipodium Regulation Of Cell Size	Myosin V Binding Exocytosis Regulation Of Exocytosis GTP-dependent Protein Binding Secretion By Cell Secretion Regulation Of Secretion By Cell Regulation Of Secretion Synaptic Vesicle Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Vesicle-mediated Transport In Synapse GTPase Activity Positive Regulation Of Secretion Regulated Exocytosis GTP Binding Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Priming Vesicle-mediated Transport GDP Binding Regulation Of Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Exocytosis Secretory Granule Calcium-ion Regulated Exocytosis Establishment Of Vesicle Localization Protein Domain Specific Binding Positive Regulation Of Transport Synaptic Vesicle Transport Acrosomal Vesicle Exocytosis Terminal Bouton Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Presynaptic Active Zone Vesicle Localization Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Regulated Secretory Pathway Organelle Localization Regulation Of Synaptic Vesicle Exocytosis Maintenance Of Presynaptic Active Zone Structure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Protein Localization Endosome Presynaptic Active Zone Organization Vesicle Docking