RNF113A and UBE2U

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF113A	UBE2U
Description		ring finger protein 113A	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome	HULC Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair MRNA Processing DNA Damage Response RNA Splicing Protein Ubiquitination SnoRNA Splicing Negative Regulation Of Chemokine-mediated Signaling Pathway	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		mRNA Splicing - Major Pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Severe bacterial meningitis ( 31092817)
Interacting Genes		10 interacting genes: CCAR1 CXCR4 PPP4R3A RBM39 SMYD3 SNRNP200 TERF2 TRIM8 UBE2D3 UBE2U	69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		7737	148581
HPRD ID		06760	14599
Ensembl ID		ENSG00000125352	ENSG00000177414
Uniprot IDs		O15541	A0A0A0MRP4 A0A140VJY9 Q5VVX9
PDB IDs		5Z56 5Z58 6FF4 6FF7 7DVQ 7QTT 8CH6 8I0R 8I0S 8I0T 8I0U	1YRV
Enriched GO Terms of Interacting Partners?		Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination DNA Damage Response Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Telomere Single Strand Break Repair Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Post-translational Protein Modification Protein Polyubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity C-X-C Motif Chemokine 12 Receptor Activity Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Cis Assembly Of Pre-catalytic Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of T-circle Formation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Nucleoplasm Negative Regulation Of Mitotic Recombination Histone H3K36 Dimethyltransferase Activity Telomerase Activity Protection From Non-homologous End Joining At Telomere Response To Stress Regulation Of Mitotic Recombination Shelterin Complex Nucleic Acid Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process CXCL12-activated CXCR4 Signaling Pathway Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway RS Domain Binding U1 SnRNP Binding Protein Phosphatase 4 Complex Histone H4 Methyltransferase Activity HULC Complex Negative Regulation Of Telomere Capping Regulation Of Metabolic Process Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Histone H3K4 Trimethyltransferase Activity	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing
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