RNF113A and SMYD3

Number of citations: 55 (PubMedID 35819319)
Data Source: BioGRID (enzymatic study)

		RNF113A	SMYD3
Name		ring finger protein 113A	SET and MYND domain containing 3
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair MRNA Processing DNA Damage Response RNA Splicing Protein Ubiquitination SnoRNA Splicing Negative Regulation Of Chemokine-mediated Signaling Pathway	Chromatin Organization Nucleosome Assembly Myotube Cell Development Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways		mRNA Splicing - Major Pathway	PKMTs methylate histone lysines
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 ) Blood metabolite levels ( 26401656 ) Coffee consumption ( 31046077 ) DHEAS levels ( 34748635 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) Gut microbiota relative abundance (Bifidobacterium) ( 33208821 ) Malaria ( 31844061 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1 ( 26634245 ) PR interval ( 32439900 ) Renal underexcretion gout ( 32238385 ) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319 ) Systemic lupus erythematosus ( 29848360 ) Upper eyelid sagging severity ( 24869959 )
Novel Interactors		None recorded	1 novel interactors: SCCPDH
Interacting Genes		10 interacting genes: CCAR1 CXCR4 PPP4R3A RBM39 SMYD3 SNRNP200 TERF2 TRIM8 UBE2D3 UBE2U	25 interacting genes: APP CAMK2B CFTR CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 LCOR MAP3K2 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K RNF113A SHC3 TRIT1 VANGL1 ZNF557
Entrez ID		7737	64754
HPRD ID		06760	12297
Ensembl ID		ENSG00000125352	ENSG00000185420
Uniprot IDs		O15541	B3KN46 Q9H7B4
PDB IDs		5Z56 5Z58 6FF4 6FF7 7DVQ 7QTT 8CH6 8I0R 8I0S 8I0T 8I0U	3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 6ZRB 7BJ1 7O2A 7O2B 7O2C 7QLB 7QNR 7QNU 8OWO
GO Terms Enriched among Interactors		Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination DNA Damage Response Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Telomere Single Strand Break Repair Telomeric Loop Formation Negative Regulation Of DNA Recombination At Telomere Post-translational Protein Modification Protein Polyubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity C-X-C Motif Chemokine 12 Receptor Activity Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) Cis Assembly Of Pre-catalytic Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of T-circle Formation Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Nucleoplasm Negative Regulation Of Mitotic Recombination Histone H3K36 Dimethyltransferase Activity Telomerase Activity Protection From Non-homologous End Joining At Telomere Response To Stress Regulation Of Mitotic Recombination Shelterin Complex Nucleic Acid Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process CXCL12-activated CXCR4 Signaling Pathway Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway RS Domain Binding U1 SnRNP Binding Protein Phosphatase 4 Complex Histone H4 Methyltransferase Activity HULC Complex Negative Regulation Of Telomere Capping Regulation Of Metabolic Process Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Histone H3K4 Trimethyltransferase Activity	Nucleus Pronucleus Transcription Corepressor Binding Chromatin Silencing Complex