PRKDC and TREX1

Number of citations of the paper that reports this interaction (PubMedID 15758953)
0

Data Source:
HPRD (in vivo)

		PRKDC	TREX1
Description		protein kinase, DNA-activated, catalytic subunit	three prime repair exonuclease 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Membrane Protein-DNA Complex Nuclear Replication Fork
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Domain Specific Binding U3 SnoRNA Binding Histone H2AXS139 Kinase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity DNA Binding, Bending Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding
	Biological Process	Maturation Of 5.8S RRNA Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Immature B Cell Differentiation Pro-B Cell Differentiation T Cell Lineage Commitment Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Protein Phosphorylation DNA Damage Response Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Response To Gamma Radiation Telomere Capping Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Lymphocyte Differentiation Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Protein Destabilization Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Small-subunit Processome Assembly Ectopic Germ Cell Programmed Cell Death Protein Modification Process Ribosome Biogenesis Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Protein Localization To Chromatin Regulation Of Cellular Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Platelet Formation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	DNA Damage Checkpoint Signaling Blood Vessel Development Kidney Development Adaptive Immune Response Organ Or Tissue Specific Immune Response Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Catabolic Process DNA Recombination Inflammatory Response Immune Response DNA Damage Response Determination Of Adult Lifespan Response To UV Regulation Of Gene Expression Regulation Of Fatty Acid Metabolic Process Regulation Of Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Retrotransposition Regulation Of Type I Interferon Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To UV Cellular Response To Interferon-beta Apoptotic Cell Clearance Regulation Of Cellular Respiration Innate Immune Response Regulation Of Innate Immune Response Establishment Of Protein Localization Negative Regulation Of Innate Immune Response Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Type I Interferon Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Immune Complex Formation CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization
Pathways		Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins	Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs		Caffeine SF1126
Diseases			Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS		Adult body size ( 32376654) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		94 interacting genes: ABL1 AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CEBPA CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C DUX4 E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB IKBKG ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NEIL3 NR3C1 PARP1 PCNA PDX1 PGR PIDD1 POU2F1 PPP6R1 PPP6R3 PRKAG1 PRKCD PTEN RAD17 RASSF1 RNF10 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TP53 TREX1 TTC3 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A	48 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC71A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1
Entrez ID		5591	11277
HPRD ID		02941	09423
Ensembl ID		ENSG00000253729	ENSG00000213689
Uniprot IDs		P78527	Q5TZT0 Q9NSU2
PDB IDs		5LUQ 5W1R 5Y3R 6ZFP 6ZH2 6ZH4 6ZH6 6ZH8 6ZHA 6ZHE 7K0Y 7K10 7K11 7K19 7K1B 7K1J 7K1K 7K1N 7LT3 7NFC 7NFE 7OTM 7OTP 7OTV 7OTW 7OTY 7SGL 7SU3 7SUD 7TYR 7Z87 7Z88 8BH3 8BHV 8BHY 8BOT 8EZ9 8EZA 8EZB 8RD4	7TQN 7TQO 7TQP 7TQQ 8VL7 9AVA
Enriched GO Terms of Interacting Partners?		Nucleus Cellular Response To Stress Nucleoplasm Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Damaged DNA Binding Double-strand Break Repair Nucleic Acid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Regulation Of DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Response To Radiation Chromosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Recombination Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Response To Hormone Signal Transduction In Response To DNA Damage Negative Regulation Of Macromolecule Biosynthetic Process DNA Damage Checkpoint Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Enzyme Binding	Histone H2AXS139 Kinase Activity Membrane Chromosome, Telomeric Region Protein Localization To Site Of Double-strand Break Double-strand Break Repair Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Somatic Cell DNA Recombination Positive Regulation Of Telomerase Catalytic Core Complex Assembly Telomere Maintenance DNA Damage Checkpoint Signaling Protein Localization To Chromosome DNA-dependent Protein Kinase Activity Telomere Organization Double-strand Break Repair Via Homologous Recombination Mitotic DNA Damage Checkpoint Signaling Recombinational Repair DNA Recombination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Somatic Recombination Of Immunoglobulin Gene Segments Protein Binding MutLalpha Complex Binding Negative Regulation Of Telomere Capping Somatic Diversification Of Immunoglobulins Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Mitotic Cell Cycle Protein Localization To Organelle Chromosome Organization Negative Regulation Of Cell Cycle Phase Transition Response To Gamma Radiation Mitotic G2/M Transition Checkpoint DNA Repair Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Telomere Capping Response To Ionizing Radiation Regulation Of Double-strand Break Repair Replicative Senescence Regulation Of Cellular Response To Heat DNA Replication Endoplasmic Reticulum Damaged DNA Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA-templated DNA Replication Initiation DNA Metabolic Process Negative Regulation Of Cell Cycle Process Pexophagy Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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