PRKDC and HIST1H1A

Number of citations of the paper that reports this interaction (PMID 20356835)
8

Data Source:
BioGRID (enzymatic study)

		PRKDC	HIST1H1A
Gene Name		protein kinase, DNA-activated, catalytic polypeptide	histone cluster 1, H1a
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Nonhomologous End Joining Complex	Nucleosome Nuclear Chromatin Nuclear Euchromatin
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Poly(A) RNA Binding	Protein Binding Chromatin DNA Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint	Nucleosome Assembly Spermatogenesis
Pathways		Nonhomologous End-joining (NHEJ) Cytosolic sensors of pathogen-associated DNA Processing of DNA ends prior to end rejoining STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System	DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		83 interactors: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CHEK1 CHEK2 CHUK CIB1 CTDP1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 ERG GSK3A GSK3B GZMB H2AFX HDAC3 HIST1H1A HIST1H1C HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11A NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R2 PPP6R3 PRKCD PTS RAD17 RBBP8 RNF144A RPA1 RPA2 SGOL1 SP1 SRF THRA THRB TP53 TREX1 UBC USF1 VPRBP WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ	45 interactors: AEBP2 CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L4 NASP PARP1 PARP3 PELP1 PKN1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 SUZ12 TERF1 TERF2IP TLK1 WHSC1L1
Entrez ID		5591	3024
HPRD ID		02941	00820
Ensembl ID		ENSG00000253729	ENSG00000124610
Uniprot IDs		P78527	Q02539
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress DNA Repair Cellular Response To DNA Damage Stimulus DNA Recombination DNA Metabolic Process Double-strand Break Repair Response To Stress Immune System Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Immune System Development Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cell Cycle Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Organelle Organization Cellular Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Cell Death Death Telomere Maintenance Developmental Process Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Organ Development Mitotic Cell Cycle Process	Chromosome Organization Cell Cycle Chromatin Organization Chromatin Modification Regulation Of Cell Cycle Organelle Organization Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Histone Modification Regulation Of Metabolic Process Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Phosphorylation Regulation Of Mitotic Cell Cycle Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle DNA Metabolic Process Cellular Response To Stress Response To Stress Histone Phosphorylation Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Cellular Metabolic Process Regulation Of Cell Cycle Process Phosphorylation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic
Tagcloud ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?