PRKDC and AP1B1

Number of citations of the paper that reports this interaction (PubMedID 10608806)
0

Data Source:
BioGRID (unspecified method)

		PRKDC	AP1B1
Description		protein kinase, DNA-activated, catalytic subunit	adaptor related protein complex 1 subunit beta 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System Membrane Membrane Coat AP-1 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Domain Specific Binding U3 SnoRNA Binding Histone H2AXS139 Kinase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Maturation Of 5.8S RRNA Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Immature B Cell Differentiation Pro-B Cell Differentiation T Cell Lineage Commitment Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Protein Phosphorylation DNA Damage Response Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Response To Gamma Radiation Telomere Capping Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Lymphocyte Differentiation Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Protein Destabilization Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Small-subunit Processome Assembly Ectopic Germ Cell Programmed Cell Death Protein Modification Process Ribosome Biogenesis Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Protein Localization To Chromatin Regulation Of Cellular Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Platelet Formation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Kidney Development Intracellular Protein Transport Determination Of Left/right Symmetry Heart Development Protein Transport Vesicle-mediated Transport Platelet Dense Granule Organization Basolateral Protein Secretion Melanosome Assembly
Pathways		Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs		Caffeine SF1126
Diseases
GWAS		Adult body size ( 32376654) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494)	Aspartate aminotransferase levels ( 33547301) Carotid atherosclerosis in HIV infection ( 20009918) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Pancreatic cancer ( 25086665) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		94 interacting genes: ABL1 AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CEBPA CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C DUX4 E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB IKBKG ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NEIL3 NR3C1 PARP1 PCNA PDX1 PGR PIDD1 POU2F1 PPP6R1 PPP6R3 PRKAG1 PRKCD PTEN RAD17 RASSF1 RNF10 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TP53 TREX1 TTC3 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A	45 interacting genes: - AGR3 AP1G1 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CEBPA CLTC CREBBP CRYBB1 FARS2 FILNC1 FMNL2 FNDC11 GPANK1 GTF2I KIF13A LDLRAP1 MLH1 MSGN1 MTNR1B MYG1 NECAP1 NTRK2 NUP54 PIP5K1C PLK2 POM121 PRKDC PSORS1C2 RNF39 SHBG SLC2A8 SMAD2 TBC1D22B TSGA10IP U2AF1
Entrez ID		5591	162
HPRD ID		02941	02541
Ensembl ID		ENSG00000253729	ENSG00000100280
Uniprot IDs		P78527	Q10567
PDB IDs		5LUQ 5W1R 5Y3R 6ZFP 6ZH2 6ZH4 6ZH6 6ZH8 6ZHA 6ZHE 7K0Y 7K10 7K11 7K19 7K1B 7K1J 7K1K 7K1N 7LT3 7NFC 7NFE 7OTM 7OTP 7OTV 7OTW 7OTY 7SGL 7SU3 7SUD 7TYR 7Z87 7Z88 8BH3 8BHV 8BHY 8BOT 8EZ9 8EZA 8EZB 8RD4	4HMY 4P6Z 6CM9 6CRI 6D83 6D84 6DFF 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9T 8D9U 8D9V 8D9W
Enriched GO Terms of Interacting Partners?		Nucleus Cellular Response To Stress Nucleoplasm Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Damaged DNA Binding Double-strand Break Repair Nucleic Acid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Regulation Of DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Response To Radiation Chromosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Recombination Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Response To Hormone Signal Transduction In Response To DNA Damage Negative Regulation Of Macromolecule Biosynthetic Process DNA Damage Checkpoint Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Enzyme Binding	Histone H2AXS139 Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Presynaptic Endocytosis Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Heat Intracellular Protein Localization Regulation Of Cell Cycle Clathrin Adaptor Activity Negative Regulation Of Cell Cycle Process Establishment Of Protein Localization DNA-dependent Protein Kinase Activity Intracellular Protein Transport Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Cell Cycle Phase Transition Clathrin-coated Pit Protein Transport Basolateral Protein Secretion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Cell Cycle Clathrin-coated Vesicle Membrane Vesicle-mediated Transport In Synapse MutSalpha Complex Binding Homologous Recombination Synaptic Vesicle Endocytosis Negative Regulation Of Mitotic Nuclear Division Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomere Localization Protein Localization To Chromosome Somatic Cell DNA Recombination Trans-Golgi Network Membrane Endocytosis Somitogenesis Meiotic Sister Chromatid Cohesion Male Meiotic Nuclear Division Nucleotide Binding Regulation Of Receptor-mediated Endocytosis Segmentation Response To Gamma Radiation Mitotic G2/M Transition Checkpoint
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