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PRKDC and ABL1
Number of citations of the paper that reports this interaction (PubMedID
9312071
)
0
Data Source:
HPRD
(in vitro)
PRKDC
ABL1
Description
protein kinase, DNA-activated, catalytic subunit
ABL proto-oncogene 1, non-receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Ruffle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Postsynaptic Density
Actin Cytoskeleton
Membrane
Nuclear Body
Dendrite
Growth Cone
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
DNA Binding
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Histone H2AXS139 Kinase Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Delta-catenin Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Maturation Of 5.8S RRNA
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Immature B Cell Differentiation
Pro-B Cell Differentiation
T Cell Lineage Commitment
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Protein Phosphorylation
DNA Damage Response
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Response To Gamma Radiation
Telomere Capping
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Lymphocyte Differentiation
Replication Fork Processing
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Destabilization
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Protein Modification Process
Ribosome Biogenesis
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromatin
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Alternative Nonhomologous End Joining
DNA Repair-dependent Chromatin Remodeling
CGAS/STING Signaling Pathway
Negative Regulation Of CGAS/STING Signaling Pathway
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Immune Effector Process
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Immune Response-activating Cell Surface Receptor Signaling Pathway
DNA Repair
Mismatch Repair
Regulation Of DNA-templated Transcription
Endocytosis
Phagocytosis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Learning Or Memory
Associative Learning
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Post-embryonic Development
Regulation Of Gene Expression
Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Endothelial Cell Migration
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Actin Filament Polymerization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Neuron Differentiation
BMP Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Stress
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Protein Modification Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
B Cell Proliferation
Regulation Of Cell Population Proliferation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Endothelial Cell Migration
Regulation Of T Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Vasoconstriction
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Platelet-derived Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Spleen Development
Thymus Development
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Myoblast Proliferation
Positive Regulation Of Stress Fiber Assembly
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Cardiac Muscle Cell Proliferation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Epinephrine
Circulatory System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Cellular Senescence
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
Cell-cell Adhesion
Regulation Of Postsynaptic Specialization Assembly
Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Dendrite Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Long-term Synaptic Potentiation
Cellular Response To Oxygen-containing Compound
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Intracellular Signal Transduction
Regulation Of Extracellular Matrix Organization
Positive Regulation Of Extracellular Matrix Organization
Podocyte Apoptotic Process
Cellular Response To Dopamine
Positive Regulation Of Establishment Of T Cell Polarity
DN4 Thymocyte Differentiation
Protein Localization To Cytoplasmic Microtubule Plus-end
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Blood Vessel Branching
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of T Cell Migration
Regulation Of Cellular Senescence
Negative Regulation Of Cellular Senescence
Pathways
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Caffeine
SF1126
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
PD-166326
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Fostamatinib
Brigatinib
Radotinib
Asciminib
Umbralisib
Diseases
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Chronic myeloid leukemia (CML)
GWAS
Adult body size (
32376654
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Lymphocyte count (
32888494
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Response to amphetamines (
22952603
)
White blood cell count (
32888494
)
Interacting Genes
94 interacting genes:
ABL1
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CEBPA
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
IKBKG
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NEIL3
NR3C1
PARP1
PCNA
PDX1
PGR
PIDD1
POU2F1
PPP6R1
PPP6R3
PRKAG1
PRKCD
PTEN
RAD17
RASSF1
RNF10
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TP53
TREX1
TTC3
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
167 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
AR
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
EPS15L1
ERBB2
ERBB3
ERBB4
EVL
FBXO7
FOSL1
GJA8
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HERC1
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
KRT31
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFAT5
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PHACTR4
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
Entrez ID
5591
25
HPRD ID
02941
01809
Ensembl ID
ENSG00000253729
ENSG00000097007
Uniprot IDs
P78527
P00519
Q59FK4
PDB IDs
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
7K0Y
7K10
7K11
7K19
7K1B
7K1J
7K1K
7K1N
7LT3
7NFC
7NFE
7OTM
7OTP
7OTV
7OTW
7OTY
7SGL
7SU3
7SUD
7TYR
7Z87
7Z88
8BH3
8BHV
8BHY
8BOT
8EZ9
8EZA
8EZB
8RD4
1AB2
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
6XR6
6XR7
6XRG
7CC2
7DT2
7N9G
7PVQ
7PVR
7PVS
7PVV
7PW2
7W7X
7W7Y
8H7F
8H7H
8I7S
8I7T
8I7Z
8SSN
Enriched GO Terms of Interacting Partners
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Nucleus
Cellular Response To Stress
Nucleoplasm
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
DNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
Nucleic Acid Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Response To Radiation
Chromosome Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
DNA Recombination
Nucleobase-containing Compound Metabolic Process
Cellular Response To Radiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Ionizing Radiation
Response To Hormone
Signal Transduction In Response To DNA Damage
Negative Regulation Of Macromolecule Biosynthetic Process
DNA Damage Checkpoint Signaling
Regulation Of Cellular Response To Stress
Negative Regulation Of Biosynthetic Process
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Enzyme Binding
Intracellular Signal Transduction
Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cytosol
Regulation Of Intracellular Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cellular Component Organization
SH3 Domain Binding
Cytoplasm
Phosphotyrosine Residue Binding
Protein Phosphorylation
Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Developmental Process
Regulation Of Apoptotic Process
Phosphorylation
Protein-containing Complex
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cellular Response To Stress
Plasma Membrane
Enzyme Binding
Peptidyl-tyrosine Phosphorylation
Regulation Of Developmental Process
Regulation Of Protein Localization
Protein Tyrosine Kinase Activity
Regulation Of Actin Filament-based Process
Immune System Process
Protein Kinase Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Projection Organization
Negative Regulation Of Apoptotic Process
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Growth Factor Stimulus
Cellular Developmental Process
DNA Damage Response
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Negative Regulation Of Signal Transduction
Regulation Of Immune System Process
Regulation Of MAPK Cascade
Response To Stress
Regulation Of Cell Population Proliferation
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