PRKDC and LYN

Number of citations of the paper that reports this interaction (PubMedID 9748231)
0

Data Source:
HPRD (in vitro)

		PRKDC	LYN
Description		protein kinase, DNA-activated, catalytic subunit	LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Crista Endocytic Vesicle Membrane Mitochondrial Membrane Protein-containing Complex Integrin Alpha2-beta1 Complex Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Domain Specific Binding U3 SnoRNA Binding Histone H2AXS139 Kinase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Enzyme Binding Signaling Receptor Activator Activity Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Transmembrane Transporter Binding Protein-containing Complex Binding Ephrin Receptor Binding Phosphoprotein Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Maturation Of 5.8S RRNA Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Immature B Cell Differentiation Pro-B Cell Differentiation T Cell Lineage Commitment Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Protein Phosphorylation DNA Damage Response Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Response To Gamma Radiation Telomere Capping Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Lymphocyte Differentiation Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Protein Destabilization Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Small-subunit Processome Assembly Ectopic Germ Cell Programmed Cell Death Protein Modification Process Ribosome Biogenesis Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Protein Localization To Chromatin Regulation Of Cellular Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Platelet Formation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	DNA Damage Checkpoint Signaling Cell Morphogenesis B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of B Cell Apoptotic Process Protein Phosphorylation Autophagy Response To Stress Inflammatory Response DNA Damage Response Response To Sterol Depletion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Fatty Acid Transport Peptidyl-tyrosine Phosphorylation Hemopoiesis Erythrocyte Differentiation Eosinophil Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-5-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis C-X-C Chemokine Receptor CXCR4 Signaling Pathway B Cell Proliferation Positive Regulation Of Phosphorylation Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Lipid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Neuroinflammatory Response Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways		Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins	GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine SF1126	Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494)	Granulocyte count ( 27863252) Height ( 18391951) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Platelet count ( 32888494) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 27863252 32888494)
Interacting Genes		94 interacting genes: ABL1 AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CEBPA CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C DUX4 E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB IKBKG ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NEIL3 NR3C1 PARP1 PCNA PDX1 PGR PIDD1 POU2F1 PPP6R1 PPP6R3 PRKAG1 PRKCD PTEN RAD17 RASSF1 RNF10 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TP53 TREX1 TTC3 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A	124 interacting genes: ACTB ADAM15 AR BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 COASY CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PRRG4 PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SOCS1 SPHK1 SPHK2 STAT3 SYK TEC TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119
Entrez ID		5591	4067
HPRD ID		02941	01301
Ensembl ID		ENSG00000253729	ENSG00000254087
Uniprot IDs		P78527	A8K379 B4DQ79 P07948 Q6NUK7
PDB IDs		5LUQ 5W1R 5Y3R 6ZFP 6ZH2 6ZH4 6ZH6 6ZH8 6ZHA 6ZHE 7K0Y 7K10 7K11 7K19 7K1B 7K1J 7K1K 7K1N 7LT3 7NFC 7NFE 7OTM 7OTP 7OTV 7OTW 7OTY 7SGL 7SU3 7SUD 7TYR 7Z87 7Z88 8BH3 8BHV 8BHY 8BOT 8EZ9 8EZA 8EZB 8RD4	1W1F 1WA7 3A4O 5XY1 6NMW 8WFF
Enriched GO Terms of Interacting Partners?		Nucleus Cellular Response To Stress Nucleoplasm Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Damaged DNA Binding Double-strand Break Repair Nucleic Acid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Regulation Of DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Response To Radiation Chromosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Recombination Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Response To Hormone Signal Transduction In Response To DNA Damage Negative Regulation Of Macromolecule Biosynthetic Process DNA Damage Checkpoint Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Enzyme Binding	Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Plasma Membrane Antigen Receptor-mediated Signaling Pathway Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Regulation Of Apoptotic Process Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling B Cell Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Adaptive Immune Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Cell Activation Immune Response T Cell Receptor Signaling Pathway Protein Kinase Activity Negative Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Protein Phosphorylation Regulation Of Multicellular Organismal Process B Cell Activation Regulation Of Transport Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Cell Activation Regulation Of MAPK Cascade External Side Of Plasma Membrane Leukocyte Activation Regulation Of Leukocyte Proliferation
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