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PRKDC and HDAC3
Number of citations of the paper that reports this interaction (PubMedID
17242407
)
0
Data Source:
BioGRID
(enzymatic study)
PRKDC
HDAC3
Description
protein kinase, DNA-activated, catalytic subunit
histone deacetylase 3
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Transcription Repressor Complex
Mitotic Spindle
Molecular Function
Nucleotide Binding
DNA Binding
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Histone H2AXS139 Kinase Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Transcription Corepressor Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Hydrolase Activity
Deacetylase Activity
Enzyme Binding
Cyclin Binding
Chromatin DNA Binding
Protein Lysine Deacetylase Activity
Histone Deacetylase Binding
GTPase Binding
NF-kappaB Binding
DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein De-2-hydroxyisobutyrylase Activity
Protein Lysine Delactylase Activity
Ubiquitin-specific Protease Binding
Biological Process
Maturation Of 5.8S RRNA
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Immature B Cell Differentiation
Pro-B Cell Differentiation
T Cell Lineage Commitment
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Protein Phosphorylation
DNA Damage Response
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Response To Gamma Radiation
Telomere Capping
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Lymphocyte Differentiation
Replication Fork Processing
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Destabilization
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Protein Modification Process
Ribosome Biogenesis
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromatin
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Alternative Nonhomologous End Joining
DNA Repair-dependent Chromatin Remodeling
CGAS/STING Signaling Pathway
Negative Regulation Of CGAS/STING Signaling Pathway
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
In Utero Embryonic Development
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Transcription By RNA Polymerase II
Protein Deacetylation
Regulation Of Mitotic Cell Cycle
Epidermis Development
Response To Xenobiotic Stimulus
Gene Expression
Negative Regulation Of Myotube Differentiation
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Negative Regulation Of Interleukin-1 Production
Negative Regulation Of Tumor Necrosis Factor Production
Circadian Regulation Of Gene Expression
Protein Modification Process
Regulation Of Multicellular Organism Growth
Epigenetic Regulation Of Gene Expression
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Protein Export From Nucleus
Rhythmic Process
Spindle Assembly
Random Inactivation Of X Chromosome
Neural Precursor Cell Proliferation
Establishment Of Skin Barrier
Cellular Response To Mechanical Stimulus
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Fluid Shear Stress
Response To Dexamethasone
Negative Regulation Of Ferroptosis
Positive Regulation Of Cold-induced Thermogenesis
DNA Repair-dependent Chromatin Remodeling
Positive Regulation Of Ferroptosis
Cornified Envelope Assembly
Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
p75NTR negatively regulates cell cycle via SC1
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Association of TriC/CCT with target proteins during biosynthesis
Regulation of lipid metabolism by PPARalpha
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
STAT3 nuclear events downstream of ALK signaling
Cytoprotection by HMOX1
Heme signaling
Heme signaling
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Caffeine
SF1126
Valproic acid
Decitabine
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Phenylbutyric acid
Mocetinostat
Entinostat
Abexinostat
Givinostat
Pyroxamide
Diseases
GWAS
Adult body size (
32376654
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Interacting Genes
94 interacting genes:
ABL1
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CEBPA
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
IKBKG
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NEIL3
NR3C1
PARP1
PCNA
PDX1
PGR
PIDD1
POU2F1
PPP6R1
PPP6R3
PRKAG1
PRKCD
PTEN
RAD17
RASSF1
RNF10
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TP53
TREX1
TTC3
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
103 interacting genes:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRIP1
BRMS1
CBFA2T3
CCN5
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
CUL4B
DAXX
DHX30
EED
ELL
EP300
ESR1
EWSR1
GATA1
GATA2
GATA3
GCM1
GPS2
GTF2I
GTF2IRD1
H2AC1
H2BC1
H3C1
H4C1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1A
HIF1AN
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
XPO1
YY1
ZBTB16
Entrez ID
5591
8841
HPRD ID
02941
08950
Ensembl ID
ENSG00000253729
ENSG00000171720
Uniprot IDs
P78527
O15379
PDB IDs
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
7K0Y
7K10
7K11
7K19
7K1B
7K1J
7K1K
7K1N
7LT3
7NFC
7NFE
7OTM
7OTP
7OTV
7OTW
7OTY
7SGL
7SU3
7SUD
7TYR
7Z87
7Z88
8BH3
8BHV
8BHY
8BOT
8EZ9
8EZA
8EZB
8RD4
4A69
Enriched GO Terms of Interacting Partners
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Nucleus
Cellular Response To Stress
Nucleoplasm
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
DNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
Nucleic Acid Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Response To Radiation
Chromosome Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
DNA Recombination
Nucleobase-containing Compound Metabolic Process
Cellular Response To Radiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Ionizing Radiation
Response To Hormone
Signal Transduction In Response To DNA Damage
Negative Regulation Of Macromolecule Biosynthetic Process
DNA Damage Checkpoint Signaling
Regulation Of Cellular Response To Stress
Negative Regulation Of Biosynthetic Process
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Enzyme Binding
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Histone Deacetylase Binding
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Chromatin
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of RNA Metabolic Process
DNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Cis-regulatory Region Binding
DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Cell Differentiation
Transcription Repressor Complex
Transcription Regulator Complex
DNA-binding Transcription Factor Binding
Transcription By RNA Polymerase II
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of MiRNA Transcription
Chromatin Organization
Transcription Coactivator Binding
Regulation Of MiRNA Metabolic Process
Regulation Of Developmental Process
Histone Deacetylase Complex
DNA-binding Transcription Factor Activity
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