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PRKDC and EIF4EBP1
Number of citations of the paper that reports this interaction (PubMedID
10713094
)
0
Data Source:
BioGRID
(enzymatic study)
PRKDC
EIF4EBP1
Description
protein kinase, DNA-activated, catalytic subunit
eukaryotic translation initiation factor 4E binding protein 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
DNA Binding
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Histone H2AXS139 Kinase Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Protein Binding
Eukaryotic Initiation Factor 4E Binding
Translation Repressor Activity
Translation Initiation Factor Binding
Biological Process
Maturation Of 5.8S RRNA
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Immature B Cell Differentiation
Pro-B Cell Differentiation
T Cell Lineage Commitment
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Protein Phosphorylation
DNA Damage Response
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Response To Gamma Radiation
Telomere Capping
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Lymphocyte Differentiation
Replication Fork Processing
Mitotic G1 DNA Damage Checkpoint Signaling
Protein Destabilization
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Protein Modification Process
Ribosome Biogenesis
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromatin
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Alternative Nonhomologous End Joining
DNA Repair-dependent Chromatin Remodeling
CGAS/STING Signaling Pathway
Negative Regulation Of CGAS/STING Signaling Pathway
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Translation
Negative Regulation Of Translation
TOR Signaling
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Translational Initiation
Pathways
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
mTORC1-mediated signalling
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs
Caffeine
SF1126
Diseases
GWAS
Adult body size (
32376654
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Menopause (age at onset) (
29773799
)
Interacting Genes
94 interacting genes:
ABL1
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CEBPA
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
IKBKG
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NEIL3
NR3C1
PARP1
PCNA
PDX1
PGR
PIDD1
POU2F1
PPP6R1
PPP6R3
PRKAG1
PRKCD
PTEN
RAD17
RASSF1
RNF10
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TP53
TREX1
TTC3
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
38 interacting genes:
AKT1
ATM
BUB1
CHTF8
CSNK2A1
CSNK2A2
DDIT4L
EIF4E
EIF4E1B
EIF4E2
GSK3B
IRAK4
LATS1
LMO2
LRRK2
MAPK1
MAPK14
MAPKAPK5
MEOX1
MLST8
MTOR
MVD
PICK1
POU6F2
PPP2CA
PRKCA
PRKDC
PTPA
REL
RHEBL1
RICTOR
RORC
RPS6KA5
RPS6KB1
RPTOR
STK3
TCF4
ZNF655
Entrez ID
5591
1978
HPRD ID
02941
03746
Ensembl ID
ENSG00000253729
ENSG00000187840
Uniprot IDs
P78527
Q13541
PDB IDs
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
7K0Y
7K10
7K11
7K19
7K1B
7K1J
7K1K
7K1N
7LT3
7NFC
7NFE
7OTM
7OTP
7OTV
7OTW
7OTY
7SGL
7SU3
7SUD
7TYR
7Z87
7Z88
8BH3
8BHV
8BHY
8BOT
8EZ9
8EZA
8EZB
8RD4
1EJ4
1EJH
1WKW
2JGB
2JGC
2V8W
2V8X
2V8Y
3HXG
3HXI
3M93
3M94
3U7X
4UED
5BXV
5EKV
5NVN
5WBJ
6BCU
6BCX
8RCH
8RCK
8RCN
Enriched GO Terms of Interacting Partners
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Nucleus
Cellular Response To Stress
Nucleoplasm
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
DNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Damaged DNA Binding
Double-strand Break Repair
Nucleic Acid Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Response To Radiation
Chromosome Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
DNA Recombination
Nucleobase-containing Compound Metabolic Process
Cellular Response To Radiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Ionizing Radiation
Response To Hormone
Signal Transduction In Response To DNA Damage
Negative Regulation Of Macromolecule Biosynthetic Process
DNA Damage Checkpoint Signaling
Regulation Of Cellular Response To Stress
Negative Regulation Of Biosynthetic Process
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Enzyme Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase Activity
Kinase Activity
Intracellular Signal Transduction
Protein Phosphorylation
ATP Binding
Phosphorylation
TOR Signaling
Nucleotide Binding
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Macromolecule Biosynthetic Process
Intracellular Signaling Cassette
Negative Regulation Of Catabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of TOR Signaling
Regulation Of Translation
Regulation Of Gene Expression
TORC2 Signaling
Positive Regulation Of Cellular Component Organization
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Growth
Regulation Of Signal Transduction
Post-transcriptional Regulation Of Gene Expression
Regulation Of Autophagy
Negative Regulation Of Signal Transduction
Signal Transduction
Regulation Of Cell Cycle
Regulation Of Apoptotic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Programmed Cell Death
Positive Regulation Of Intracellular Signal Transduction
Transferase Activity
Negative Regulation Of Metabolic Process
Negative Regulation Of Autophagy
Positive Regulation Of Growth
Cellular Response To Nutrient Levels
TORC1 Signaling
Response To Nutrient Levels
Protein Metabolic Process
Regulation Of TORC2 Signaling
Positive Regulation Of Protein-containing Complex Assembly
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Tagcloud (Difference)
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Tagcloud (Intersection)
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