WEE1 and YWHAQ

Number of citations of the paper that reports this interaction (PMID 15161933)
63

Data Source:
BioGRID (pull down)

		WEE1	YWHAQ
Gene Name		WEE1 G2 checkpoint kinase	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Mitotic Nuclear Division Blood Coagulation Peptidyl-tyrosine Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Regulation Of Cell Cycle	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		G2/M DNA damage checkpoint G2/M Checkpoints G2/M Transition S Phase Cyclin E associated events during G1/S transition Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Mitotic G2-G2/M phases Polo-like kinase mediated events G2/M DNA replication checkpoint	Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Heart rate variability traits ( 22174390)
Protein-Protein Interactions		21 interactors: BRD8 BRSK1 BRSK2 BTRC CASP3 CDCA3 CDK1 CDK2 CRK CSNK2A1 FBXW11 NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAQ YWHAZ	231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2
Entrez ID		7465	10971
HPRD ID		01907	00886
Ensembl ID		ENSG00000166483	ENSG00000134308
Uniprot IDs		P30291 Q86V29	B4DMT8 P27348
PDB IDs		1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0	2BTP
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cellular Response To Stimulus Mitotic Cell Cycle Cell Communication Positive Regulation Of Intracellular Transport Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Cellular Protein Catabolic Process Signal Transduction Cellular Macromolecule Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Catabolic Process Cellular Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Apoptotic Process Regulation Of Establishment Of Protein Localization Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Proteolysis Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity
Tagcloud ?		arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Difference) ?		arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Intersection) ?