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WEE1 and BTRC
Number of citations of the paper that reports this interaction (PubMedID
15070733
)
43
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vivo)
WEE1
BTRC
Description
WEE1 G2 checkpoint kinase
beta-transducin repeat containing E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Binding
Beta-catenin Binding
Ligase Activity
Protein Phosphorylated Amino Acid Binding
Protein Dimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Establishment Of Cell Polarity
Positive Regulation Of DNA Replication
Neuron Projection Morphogenesis
Cell Division
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Protein Dephosphorylation
Ubiquitin-dependent Protein Catabolic Process
Lysosome Organization
Signal Transduction
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Wnt Signaling Pathway
Protein Ubiquitination
Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Cellular Response To Nutrient Levels
Mammary Gland Epithelial Cell Proliferation
Non-canonical NF-kappaB Signal Transduction
TORC1 Signaling
Regulation Of Circadian Rhythm
Positive Regulation Of Circadian Rhythm
Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Rhythmic Process
T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Cell Cycle
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Negative Regulation Of TORC1 Signaling
Pathways
Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Factors involved in megakaryocyte development and platelet production
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Neddylation
Interleukin-1 signaling
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Drugs
9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE
9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE
4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione
3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID
8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide
MK-1775
Fostamatinib
Diseases
GWAS
Cutaneous squamous cell carcinoma (
32041948
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Platelet distribution width (
32888494
)
Diastolic blood pressure (
30224653
)
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) (
33987465
)
Red blood cell count (
29403010
)
Red cell distribution width (
32888494
)
Smoking initiation (
33082346
)
Smoking status (ever vs never smokers) (
30643258
)
Walking pace (
33128006
)
Interacting Genes
27 interacting genes:
AKT1
BRD8
BRSK1
BRSK2
BTRC
CASP3
CCNA1
CCNB1
CDC14A
CDCA3
CDK1
CDK2
CRK
CSNK2A1
EPS15
ERRFI1
FBXW11
MAILR
NEDD4
PIN1
PLK1
SKP2
SMAD3
SMURF1
YWHAB
YWHAG
YWHAZ
94 interacting genes:
AGO2
AKT1
AMER1
ATF4
AXIN1
AXIN2
BORA
CCND1
CCNE1
CDC25A
CDC34
CDK1
CENPW
CHPF
CHUK
CP
CRYAA
CTNNB1
CUL1
DBN1
DLGAP5
E2F1
FBXW11
FBXW2
FOXO3
FZR1
GHR
GLI2
GLI3
GSK3B
HERC3
HIPK2
HNRNPU
ICE1
IKBKB
IL10RA
JUP
KDR
KEAP1
KMT5A
LINC00511
LPCAT1
MAPK1
MAPK13
MAPK14
MAPK6
MAPK9
MCL1
MDM2
MITF
MYB
NFE2
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NHSL2
PAQR3
PCDH8
PDCD4
PHF19
PLK4
PSMA3
PSMD4
RASSF5
RCAN1
RELA
RIPK4
RNF7
SKP1
SLC7A11-AS1
SMAD3
SMAD4
SMURF1
SMURF2
SUFU
TACC1
TAFAZZIN
TFE3
TIAM1
TP63
TRIB2
TRIM36
TRIM9
TSPAN15
UBC
UBE2D2
UBE2R2
UBQLN2
WEE1
WWTR1
XRCC1
ZC3H12A
Entrez ID
7465
8945
HPRD ID
01907
04596
Ensembl ID
ENSG00000166483
ENSG00000166167
Uniprot IDs
P30291
Q86V29
A0A0S2Z4P6
B2R8L3
B7Z3H4
Q9Y297
PDB IDs
1X8B
2IN6
2IO6
2Z2W
3BI6
3BIZ
3CQE
3CR0
5V5Y
5VC3
5VC4
5VC5
5VC6
5VD2
5VD4
5VD5
5VD7
5VD8
5VD9
5VDA
7N3U
8BJU
8WDK
1P22
2P64
6M90
6M91
6M92
6M93
6M94
6TTU
Enriched GO Terms of Interacting Partners
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Cell Cycle G2/M Phase Transition
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Phosphoserine Residue Binding
Protein Modification Process
Post-translational Protein Modification
Regulation Of Cell Cycle
Regulation Of Protein Localization To Nucleus
Regulation Of Protein Stability
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Cytosol
Protein Metabolic Process
Organelle Organization
Positive Regulation Of Protein Metabolic Process
Protein Catabolic Process
Cellular Response To Stress
Protein Targeting
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Localization
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Protein Catabolic Process
Protein Localization To Site Of Double-strand Break
Signal Transduction
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Metabolic Process
Protein Polyubiquitination
Macromolecule Catabolic Process
Regulation Of Signaling
Cell Cycle G1/S Phase Transition
Protein Ubiquitination
Regulation Of Cell Cycle Phase Transition
Cytoplasm
Microtubule Cytoskeleton Organization
Cell Division
Protein Kinase Binding
Protein Localization To Organelle
Response To Stress
DNA Damage Checkpoint Signaling
Proteasomal Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Peptidyl-serine Phosphorylation
Protein Modification By Small Protein Conjugation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Intracellular Protein Localization
Regulation Of Mitotic Cell Cycle
Protein Phosphorylation
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Differentiation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cytosol
Protein Catabolic Process
Nucleus
Positive Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Macromolecule Catabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Nucleoplasm
Cytoplasm
Protein Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Proteolysis
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Differentiation
Cell Surface Receptor Signaling Pathway
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Metabolic Process
Protein Modification Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Catabolic Process
Regulation Of Multicellular Organismal Development
Response To Oxidative Stress
Negative Regulation Of Cell Differentiation
Protein Ubiquitination
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Catabolic Process
Macromolecule Metabolic Process
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