WEE1 and CDCA3

Number of citations of the paper that reports this interaction (PubMedID 12679038)
0

Data Source:
HPRD (in vitro, in vivo)

		WEE1	CDCA3
Description		WEE1 G2 checkpoint kinase	cell division cycle associated 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Cytoplasm Cytosol Adherens Junction
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Of Cell Polarity Positive Regulation Of DNA Replication Neuron Projection Morphogenesis Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Ubiquitination Cell Division
Pathways		Polo-like kinase mediated events Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Factors involved in megakaryocyte development and platelet production
Drugs		9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide MK-1775 Fostamatinib
Diseases
GWAS		Cutaneous squamous cell carcinoma ( 32041948) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Platelet distribution width ( 32888494)
Interacting Genes		27 interacting genes: AKT1 BRD8 BRSK1 BRSK2 BTRC CASP3 CCNA1 CCNB1 CDC14A CDCA3 CDK1 CDK2 CRK CSNK2A1 EPS15 ERRFI1 FBXW11 MAILR NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAZ	10 interacting genes: APP BCL11A CTDSP1 CTDSP2 CUL1 SKP1 TRAF1 TRAF2 UBC WEE1
Entrez ID		7465	83461
HPRD ID		01907	09670
Ensembl ID		ENSG00000166483	ENSG00000111665
Uniprot IDs		P30291 Q86V29	F5GX58 F8WDL1 J3KMY0 Q99618
PDB IDs		1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA 7N3U 8BJU 8WDK
Enriched GO Terms of Interacting Partners?		Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphoserine Residue Binding Protein Modification Process Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Regulation Of Protein Stability Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cytosol Protein Metabolic Process Organelle Organization Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Cellular Response To Stress Protein Targeting SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Catabolic Process Protein Localization To Site Of Double-strand Break Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Signaling Cell Cycle G1/S Phase Transition Protein Ubiquitination Regulation Of Cell Cycle Phase Transition Cytoplasm Microtubule Cytoskeleton Organization Cell Division Protein Kinase Binding Protein Localization To Organelle Response To Stress DNA Damage Checkpoint Signaling Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidyl-serine Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Protein Localization Regulation Of Mitotic Cell Cycle Protein Phosphorylation	Protein Modification Process Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Thioesterase Binding Protein Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Molecular Function Activator Activity Cell Death Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Tumor Necrosis Factor Receptor Binding Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Protein Ubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Protein Polyubiquitination SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway TORC2 Complex Disassembly Negative Regulation Of Cell Cycle Process Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling TORC1 Signaling Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Phosphatase Activity
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