WEE1 and BRSK1

Number of citations: 0 (PubMedID 15150265)
Data Source: HPRD (in vitro)

		WEE1	BRSK1
Name		WEE1 G2 checkpoint kinase	BR serine/threonine kinase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Synaptic Vesicle Postsynaptic Density Cell Junction Cytoplasmic Vesicle Cell Projection Synapse Presynaptic Active Zone Cholinergic Synapse Distal Axon
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Of Cell Polarity Positive Regulation Of DNA Replication Neuron Projection Morphogenesis Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neurotransmitter Secretion Nervous System Development Axonogenesis Associative Learning Response To UV Response To Ionizing Radiation Regulation Of Synaptic Vesicle Priming Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Central Nervous System Neuron Differentiation Establishment Of Cell Polarity Neuron Differentiation Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Regulation Of Axonogenesis Centrosome Duplication Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Clustering
Pathways		Polo-like kinase mediated events Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Factors involved in megakaryocyte development and platelet production	None
Drugs		9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide MK-1775 Fostamatinib	None
GWAS		Cutaneous squamous cell carcinoma ( 32041948 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Platelet distribution width ( 32888494 )	Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 ) Menarche and menopause (age at onset) ( 19448621 ) Menopause (age at onset) ( 19448619 26414677 )
Interacting Genes		27 interacting genes: AKT1 BRD8 BRSK1 BRSK2 BTRC CASP3 CCNA1 CCNB1 CDC14A CDCA3 CDK1 CDK2 CRK CSNK2A1 EPS15 ERRFI1 FBXW11 MAILR NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAZ	8 interacting genes: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A MAPT PAK1 WEE1
Entrez ID		7465	84446
HPRD ID		01907	12533
Ensembl ID		ENSG00000166483	ENSG00000160469
Uniprot IDs		P30291 Q86V29	Q8TDC3
PDB IDs		1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA 7N3U 8BJU 8WDK	Not available
GO Terms Enriched among Interactors		Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphoserine Residue Binding Protein Modification Process Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Regulation Of Protein Stability Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cytosol Protein Metabolic Process Organelle Organization Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Cellular Response To Stress Protein Targeting SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Catabolic Process Protein Localization To Site Of Double-strand Break Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Regulation Of Signaling Cell Cycle G1/S Phase Transition Protein Ubiquitination Regulation Of Cell Cycle Phase Transition Cytoplasm Microtubule Cytoskeleton Organization Cell Division Protein Kinase Binding Protein Localization To Organelle Response To Stress DNA Damage Checkpoint Signaling Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidyl-serine Phosphorylation Protein Modification By Small Protein Conjugation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Protein Localization Regulation Of Mitotic Cell Cycle Protein Phosphorylation	Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Microtubule Polymerization Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Polymerization Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Growth Positive Regulation Of Mitotic Cell Cycle Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cell Cycle Phase Transition Positive Regulation Of Meiotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cell Growth Positive Regulation Of Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Growth Regulation Of Organelle Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Axon Extension Positive Regulation Of Cell Cycle Process Cellular Response To Heat Tubulin Binding Microtubule-based Process Regulation Of Meiotic Cell Cycle Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Organelle Organization