TNFRSF1A and PTK2

Number of citations of the paper that reports this interaction (PMID 12748169)
9

Data Source:
HPRD (in vivo)

		TNFRSF1A	PTK2
Gene Name		tumor necrosis factor receptor superfamily, member 1A	protein tyrosine kinase 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse	Stress Fiber Nucleus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Apical Plasma Membrane Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding	Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding SH2 Domain Binding
	Biological Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway	Microtubule Cytoskeleton Organization Angiogenesis Vasculogenesis Neuron Migration Placenta Development Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Embryo Development Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Regulation Of Rho GTPase Activity Regulation Of Cell Adhesion Mediated By Integrin Netrin-activated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Nucleus Localization Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Organ Growth Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Negative Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Synapse Assembly Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis
Pathways		TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway	Axon guidance DCC mediated attractive signaling Netrin mediated repulsion signals Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Programmed Cell Death EPH-Ephrin signaling NCAM signaling for neurite out-growth Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Signal regulatory protein (SIRP) family interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Signaling by VEGF Platelet activation, signaling and aggregation
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)	Response to interferon beta therapy ( 21502966)
Protein-Protein Interactions		60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	104 interactors: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SHC1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TP53 TRIO TRIP6 TSC2 VCL YES1 ZNF331
Entrez ID		7132	5747
HPRD ID		01861	02859
Ensembl ID		ENSG00000067182	ENSG00000169398
Uniprot IDs		J9PH39 P19438	E7ESA6 Q05397 Q59GM6 Q658W2
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Locomotion Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Immune System Process Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Cell Motility Chemotaxis Blood Coagulation Hemostasis Innate Immune Response Response To Growth Factor Response To Wounding Wound Healing Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Cell Adhesion Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Anatomical Structure Morphogenesis Leukocyte Migration Defense Response Regulation Of Body Fluid Levels Positive Regulation Of Protein Phosphorylation Response To Stress Axon Guidance Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Axon Development
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin
Tagcloud (Intersection) ?