PTK2 and FGR

Number of citations of the paper that reports this interaction (PMID 12387730)
2

Data Source:
HPRD (in vivo)

		PTK2	FGR
Gene Name		protein tyrosine kinase 2	FGR proto-oncogene, Src family tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Apical Plasma Membrane Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding SH2 Domain Binding	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Microtubule Cytoskeleton Organization Angiogenesis Vasculogenesis Neuron Migration Placenta Development Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Embryo Development Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Regulation Of Rho GTPase Activity Regulation Of Cell Adhesion Mediated By Integrin Netrin-activated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Nucleus Localization Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Organ Growth Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Negative Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Synapse Assembly Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis	Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Cytokine Secretion Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Cellular Response To Peptide Hormone Stimulus
Pathways		Axon guidance DCC mediated attractive signaling Netrin mediated repulsion signals Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Programmed Cell Death EPH-Ephrin signaling NCAM signaling for neurite out-growth Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Signal regulatory protein (SIRP) family interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Signaling by VEGF Platelet activation, signaling and aggregation	Platelet homeostasis Platelet sensitization by LDL Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System
Drugs
Diseases
GWAS		Response to interferon beta therapy ( 21502966)
Protein-Protein Interactions		104 interactors: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SHC1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TP53 TRIO TRIP6 TSC2 VCL YES1 ZNF331	22 interactors: ARRB1 CBL CCR3 CSK DAB2 DOK1 ERBB2 FASLG HCLS1 IKBKG INPP5D KHDRBS1 NR1I2 PTK2 SLAMF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		5747	2268
HPRD ID		02859	01288
Ensembl ID		ENSG00000169398	ENSG00000000938
Uniprot IDs		E7ESA6 Q05397 Q59GM6 Q658W2	P09769 P78453
PDB IDs		1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Locomotion Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Immune System Process Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Cell Motility Chemotaxis Blood Coagulation Hemostasis Innate Immune Response Response To Growth Factor Response To Wounding Wound Healing Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Cell Adhesion Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Anatomical Structure Morphogenesis Leukocyte Migration Defense Response Regulation Of Body Fluid Levels Positive Regulation Of Protein Phosphorylation Response To Stress Axon Guidance Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Axon Development	Signaling Cell Communication Positive Regulation Of Signal Transduction Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Response To Stimulus Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Organic Substance Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of Tissue Remodeling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transport Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Bone Resorption Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Difference) ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Intersection) ?