TNFRSF1A and CLIP3

Number of citations of the paper that reports this interaction (PMID 22297296)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TNFRSF1A	CLIP3
Gene Name		tumor necrosis factor receptor superfamily, member 1A	CAP-GLY domain containing linker protein 3
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse	Golgi Stack Trans-Golgi Network Plasma Membrane Early Endosome Membrane Trans-Golgi Network Membrane Membrane Raft Recycling Endosome Membrane
	Molecular Function	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding	Microtubule Binding Ganglioside Binding
	Biological Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Glucose Transport Peptidyl-L-cysteine S-palmitoylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of Apoptotic Process Membrane Biogenesis Fat Cell Differentiation Positive Regulation Of Endocytosis Chaperone-mediated Protein Transport Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)
Protein-Protein Interactions		60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	4 interactors: AKT1 AKT2 TNFRSF1A TNFRSF21
Entrez ID		7132	25999
HPRD ID		01861	09572
Ensembl ID		ENSG00000067182	ENSG00000105270
Uniprot IDs		J9PH39 P19438	Q96DZ5
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR	2CP0
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation	Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Establishment Of Protein Localization Myelination Axon Ensheathment Regulation Of Protein Localization Peripheral Nervous System Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Apoptotic Process Regulation Of Fatty Acid Beta-oxidation Programmed Cell Death Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Cell Death Death Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Lipid Transport Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Myelination In Peripheral Nervous System Positive Regulation Of Glucose Import Cellular Polysaccharide Biosynthetic Process Regulation Of Glycogen Metabolic Process Schwann Cell Development Positive Regulation Of Glucose Transport Polysaccharide Biosynthetic Process Negative Regulation Of Transport Regulation Of Intracellular Transport Negative Regulation Of Ion Transmembrane Transport Regulation Of Myelination Schwann Cell Differentiation Negative Regulation Of Transmembrane Transport Regulation Of Glucose Import Regulation Of Lipid Catabolic Process Glycogen Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Response To Organic Substance Cellular Response To Mechanical Stimulus Cellular Response To Hormone Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Cytokine Stimulus Polysaccharide Metabolic Process Regulation Of Protein Transport Regulation Of Fatty Acid Metabolic Process Regulation Of Glucose Transport Glial Cell Development Regulation Of Lipid Transport
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Intersection) ?