TNFRSF1A and NSMAF

Number of citations of the paper that reports this interaction (PMID 8808629)
60

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TNFRSF1A	NSMAF
Gene Name		tumor necrosis factor receptor superfamily, member 1A	neutral sphingomyelinase (N-SMase) activation associated factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse	Cytoplasm Endomembrane System Extrinsic Component Of Membrane
	Molecular Function	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding	Receptor Signaling Protein Activity Protein Binding Phospholipid Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway	Ceramide Metabolic Process Signal Transduction Endosomal Transport Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity
Pathways		TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)
Protein-Protein Interactions		60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	4 interactors: ACTB CD40 GNB2L1 TNFRSF1A
Entrez ID		7132	8439
HPRD ID		01861	09117
Ensembl ID		ENSG00000067182	ENSG00000035681
Uniprot IDs		J9PH39 P19438	Q92636
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation	Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of JAK-STAT Cascade Regulation Of Establishment Of Protein Localization Response To Wounding Positive Regulation Of Protein Phosphorylation Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Response To Mechanical Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Phosphorylation Defense Response Regulation Of Neuron Death Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Isotype Switching To IgG Isotypes Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Regulation Of Isotype Switching To IgG Isotypes Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	alternatively arrestin axin crystallin dissimilar endproducts gaiix glycation illumina microvasculature nondiabetic photoreceptor physiologically pointing rage retinopathy rodent seq sgip1 sh3 signatures sphingomyelinase spliced streptozotocin transcriptome transcripts utilize versions xenobiotic
Tagcloud (Intersection) ?