TNFRSF1A and RIPK3

Number of citations of the paper that reports this interaction (PubMedID 10339433)
0

Data Source:
HPRD (in vivo)

		TNFRSF1A	RIPK3
Description		TNF receptor superfamily member 1A	receptor interacting serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity Tumor Necrosis Factor Binding	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity
	Biological Process	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Transcription By RNA Polymerase II Prostaglandin Metabolic Process Apoptotic Process Defense Response Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Non-canonical NF-kappaB Signal Transduction Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier Regulation Of Membrane Lipid Metabolic Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Gene Expression Programmed Cell Death Activation Of Protein Kinase Activity Regulation Of Type II Interferon Production T Cell Differentiation In Thymus Protein Modification Process Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Necroptotic Signaling Pathway Execution Phase Of Necroptosis Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling	TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death SARS-CoV-1 activates/modulates innate immune responses
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases		Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 24836286) Crohn's disease ( 26192919) Eosinophil count ( 32888494) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 27386562 24076602 31604244 21833088 19525953) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 21399635 28425483 26394269) Primary biliary cirrhosis ( 22961000) White blood cell count ( 32888494)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	24 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 TRAF6 TRIM25 UTP11 XIAP ZSCAN20
Entrez ID		7132	11035
HPRD ID		01861	09315
Ensembl ID		ENSG00000067182	ENSG00000129465
Uniprot IDs		J9PH39 P19438	Q9Y572
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR 7K7A 7KP7 7KP8 7KPB 8P6Q	5V7Z 5ZCK 7DA4 7DAC 7MON 7MX3
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cytosol Programmed Cell Death Cell Death Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Tumor Necrosis Factor Receptor Binding Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Stress Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway Kinase Activity Positive Regulation Of Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Activation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation	Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Necroptotic Process Regulation Of Protein Modification Process Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Receptor Complex Ubiquitin Protein Ligase Activity Regulation Of Defense Response Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Defense Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Protein K63-linked Ubiquitination Signaling Adaptor Activity Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Transferase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Ripoptosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?