PTK2 and TRIO

Number of citations of the paper that reports this interaction (PMID 12551902)
13

Data Source:
HPRD (in vivo, in vitro)

		PTK2	TRIO
Gene Name		protein tyrosine kinase 2	trio Rho guanine nucleotide exchange factor
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Apical Plasma Membrane Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytosol
	Molecular Function	Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding SH2 Domain Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Enzyme Binding
	Biological Process	Microtubule Cytoskeleton Organization Angiogenesis Vasculogenesis Neuron Migration Placenta Development Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Embryo Development Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Regulation Of Rho GTPase Activity Regulation Of Cell Adhesion Mediated By Integrin Netrin-activated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Nucleus Localization Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Organ Growth Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Negative Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Synapse Assembly Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Axon guidance DCC mediated attractive signaling Netrin mediated repulsion signals Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Programmed Cell Death EPH-Ephrin signaling NCAM signaling for neurite out-growth Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Signal regulatory protein (SIRP) family interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Signaling by VEGF Platelet activation, signaling and aggregation	G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE DCC mediated attractive signaling p75 NTR receptor-mediated signalling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Netrin-1 signaling
Drugs
Diseases
GWAS		Response to interferon beta therapy ( 21502966)	Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		104 interactors: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SHC1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TP53 TRIO TRIP6 TSC2 VCL YES1 ZNF331	11 interactors: BLMH CDC5L DISC1 EXOC1 FLNA ITSN2 MAPRE1 PTK2 PTPRF RAC1 RHOA
Entrez ID		5747	7204
HPRD ID		02859	03537
Ensembl ID		ENSG00000169398	ENSG00000038382
Uniprot IDs		E7ESA6 Q05397 Q59GM6 Q658W2	O75962
PDB IDs		1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO	1NTY 2NZ8
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Locomotion Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Immune System Process Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Cell Motility Chemotaxis Blood Coagulation Hemostasis Innate Immune Response Response To Growth Factor Response To Wounding Wound Healing Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Cell Adhesion Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Anatomical Structure Morphogenesis Leukocyte Migration Defense Response Regulation Of Body Fluid Levels Positive Regulation Of Protein Phosphorylation Response To Stress Axon Guidance Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Axon Development	Platelet Activation Positive Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Migration Cell Motility Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cytoskeleton Organization Regulation Of Body Fluid Levels Wound Healing Locomotion Organelle Organization Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Cell Activation Positive Regulation Of Stress Fiber Assembly Response To Wounding Regulation Of Focal Adhesion Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Negative Regulation Of Axonogenesis Microtubule-based Process Cellular Localization Movement Of Cell Or Subcellular Component Regulation Of Lipid Kinase Activity Regulation Of Cell Junction Assembly Mitotic Nuclear Division Positive Regulation Of Intracellular Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Regulation Of Stress Fiber Assembly Cell Projection Morphogenesis Regulation Of Rho Protein Signal Transduction Regulation Of Cell Development Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Projection Development Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity
Tagcloud ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds
Tagcloud (Difference) ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds
Tagcloud (Intersection) ?