PTK2 and ITGB5

Number of citations of the paper that reports this interaction (PMID 11927607)
83

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		PTK2	ITGB5
Gene Name		protein tyrosine kinase 2	integrin, beta 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Apical Plasma Membrane Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Plasma Membrane Focal Adhesion Cell Surface Cell Leading Edge Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding SH2 Domain Binding	Receptor Activity Integrin Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Angiogenesis Vasculogenesis Neuron Migration Placenta Development Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Embryo Development Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Regulation Of Rho GTPase Activity Regulation Of Cell Adhesion Mediated By Integrin Netrin-activated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Nucleus Localization Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Organ Growth Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Negative Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Synapse Assembly Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Extracellular Matrix Organization Endodermal Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Stress Fiber Assembly Epithelial Cell-cell Adhesion
Pathways		Axon guidance DCC mediated attractive signaling Netrin mediated repulsion signals Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Programmed Cell Death EPH-Ephrin signaling NCAM signaling for neurite out-growth Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Signal regulatory protein (SIRP) family interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Signaling by VEGF Platelet activation, signaling and aggregation	Elastic fibre formation Smooth Muscle Contraction Non-integrin membrane-ECM interactions Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Response to interferon beta therapy ( 21502966)
Protein-Protein Interactions		104 interactors: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SHC1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TP53 TRIO TRIP6 TSC2 VCL YES1 ZNF331	34 interactors: ANXA5 CYR61 DAB1 DAB2 DOK1 EHMT2 EPS8 EWSR1 FHL2 FLNA GNB2L1 ITGA5 ITGAV ITGB3BP KRT40 KRTAP10-8 KRTAP10-9 LTBP1 LTBP3 MTUS2 MYO10 NOTCH2NL NUMB P2RY2 PAK4 PALLD PIAS2 PPARD PTK2 SNTA1 SRSF9 TLN1 TNS2 ZBTB17
Entrez ID		5747	3693
HPRD ID		02859	00949
Ensembl ID		ENSG00000169398	ENSG00000082781
Uniprot IDs		E7ESA6 Q05397 Q59GM6 Q658W2	L7RT22 P18084
PDB IDs		1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Locomotion Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Immune System Process Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Cell Motility Chemotaxis Blood Coagulation Hemostasis Innate Immune Response Response To Growth Factor Response To Wounding Wound Healing Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Cell Adhesion Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Anatomical Structure Morphogenesis Leukocyte Migration Defense Response Regulation Of Body Fluid Levels Positive Regulation Of Protein Phosphorylation Response To Stress Axon Guidance Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Axon Development	Signaling Cell Communication Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Locomotion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Cell Migration Wound Healing Cell Development Regulation Of Cell Motility Movement Of Cell Or Subcellular Component Regulation Of Locomotion Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Positive Regulation Of Protein Phosphorylation Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Chemotaxis Positive Regulation Of Phosphorylation Axon Guidance Multicellular Organismal Development Regulation Of Cell Adhesion Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Blood Coagulation Negative Regulation Of Programmed Cell Death Hemostasis Developmental Process Anatomical Structure Development Apoptotic Process Positive Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Cell Morphogenesis
Tagcloud ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Difference) ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
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