TNFRSF1A and TRPC4AP

Number of citations of the paper that reports this interaction (PMID 14585990)
6

Data Source:
HPRD (in vivo)

		TNFRSF1A	TRPC4AP
Gene Name		tumor necrosis factor receptor superfamily, member 1A	transient receptor potential cation channel, subfamily C, member 4 associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse	Plasma Membrane Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding	Protein Binding Phosphatase Binding
	Biological Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways		TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway	Ion channel transport TRP channels Stimuli-sensing channels
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)	Prothrombin time ( 22703881)
Protein-Protein Interactions		60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	9 interactors: CHMP4C CHUK IKBKB IKBKG RIPK1 TAB1 TNFRSF1A TRADD TRAF2
Entrez ID		7132	26133
HPRD ID		01861	09238
Ensembl ID		ENSG00000067182	ENSG00000100991
Uniprot IDs		J9PH39 P19438	B4E0Q1 E1P5Q0 Q8TEL6
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation	Positive Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Tumor Necrosis Factor Toll-like Receptor Signaling Pathway Response To Tumor Necrosis Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cytokine Production Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Intracellular Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Type I Interferon Production Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Regulation Of Type I Interferon Production Response To Cytokine Defense Response Protein Heterooligomerization Innate Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Intersection) ?