TNFRSF1A and TNFSF13

Number of citations of the paper that reports this interaction (PMID 10706119)
19

Data Source:
HPRD (in vitro)

		TNFRSF1A	TNFSF13
Gene Name		tumor necrosis factor receptor superfamily, member 1A	tumor necrosis factor (ligand) superfamily, member 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse	Extracellular Space Nucleoplasm Cytoplasm Cytosol External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway	Immunoglobulin Production In Mucosal Tissue Positive Regulation Of Germinal Center Formation Signal Transduction Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway	Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)	IgA levels ( 22864923) IgA nephropathy ( 22197929) IgM levels ( 23118916) Non-albumin protein levels ( 22558069)
Protein-Protein Interactions		60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	10 interactors: CAMK1D FAS FURIN SDC2 TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		7132	8741
HPRD ID		01861	05128
Ensembl ID		ENSG00000067182	ENSG00000161955
Uniprot IDs		J9PH39 P19438	B3KR02 O75888 Q2QBA2
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation	Lymphocyte Homeostasis Leukocyte Homeostasis Signal Transduction Regulation Of Lymphocyte Activation Signaling Negative Regulation Of Lymphocyte Activation Cell Communication Response To Stimulus Regulation Of Cell Activation Negative Regulation Of Leukocyte Activation Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Immune System Process B Cell Homeostasis Negative Regulation Of B Cell Activation Homeostasis Of Number Of Cells Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Organic Substance Regulation Of B Cell Proliferation Immunoglobulin Production Response To Organic Cyclic Compound Extracellular Matrix Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Extracellular Structure Organization Cellular Response To Mechanical Stimulus Negative Regulation Of Immune System Process Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Odontogenesis Of Dentin-containing Tooth T Cell Costimulation Response To External Stimulus Programmed Cell Death Positive Regulation Of Leukocyte Migration Cell Death Death Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Dendrite Development Nerve Growth Factor Production Motor Neuron Apoptotic Process Response To Steroid Hormone Extrinsic Apoptotic Signaling Pathway Regulation Of Leukocyte Migration Immune System Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Response To Tumor Necrosis Factor
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover viable
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2	aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover
Tagcloud (Intersection) ?		viable