TNFRSF1A and ATF6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TNFRSF1A	ATF6
Gene Name		tumor necrosis factor receptor superfamily, member 1A	activating transcription factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding CAMP Response Element Binding
	Biological Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Folding Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway	ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperone genes ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)	Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	14 interactors: APP ATF6B BPGM CREB1 CREB3L3 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		7132	22926
HPRD ID		01861	16118
Ensembl ID		ENSG00000067182	ENSG00000118217
Uniprot IDs		J9PH39 P19438	A8K383 P18850
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation	Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Response To Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To Unfolded Protein Response To Organonitrogen Compound Response To Endoplasmic Reticulum Stress Cellular Response To Stimulus Response To Toxic Substance Response To Hormone Small Molecule Metabolic Process Response To Drug Cellular Chemical Homeostasis Response To Stress Response To Abiotic Stimulus Erythrocyte Development Cellular Response To Nutrient Regulation Of Metabolic Process Positive Regulation Of Fat Cell Differentiation
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Intersection) ?