TNFRSF1A and SRC

  • Number of citations of the paper that reports this interaction (PMID 18606683)
  • 21
  • Data Source:
  • BioGRID (affinity chromatography technology, enzymatic study)

TNFRSF1A

SRC

Gene Name tumor necrosis factor receptor superfamily, member 1A SRC proto-oncogene, non-receptor tyrosine kinase
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065)
  • Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065)
  • Multiple sclerosis ( 19525953 21833088)
  • Primary biliary cirrhosis ( 21399635)
  • Retinopathy in non-diabetics ( 23393555)
Protein-Protein Interactions 60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1 279 interactors: ABL1 ACTN1 ADAM12 ADAM15 ADRB2 ADRB3 ADRBK1 AFAP1 AFAP1L2 AHR AKT1 ANKRD11 ANXA1 ANXA2 ANXA7 AR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP35 ARID1A ARNT ARR3 ASAP1 ATP2B4 AXL BCAR1 BCR BMX BRCA1 CA3 CARM1 CAV1 CAV2 CBL CBLC CCNA1 CD2AP CD33 CD36 CD44 CD46 CD59 CDC25C CDC37 CDCP1 CDH5 CDK5 CDKN1B CEACAM1 CEACAM3 CFL1 CHUK CLTC CNTNAP1 CORO7 CRMP1 CSK CTNNB1 CTNND1 CTTN DAB1 DAB2 DAG1 DAPP1 DDR2 DGKA DGKZ DLG4 DNM1 DNM2 DOK1 DOK2 DOK4 EFNA5 EFNB1 EFNB2 EFS EGFR EGLN1 ENO1 EP300 EPHA3 EPHA4 EPHB2 EPS8 ERBB2 ERBB3 ESR1 ESR2 ESRRA ESRRG ETS1 ETS2 EVL FARP2 FASLG FGR FHIT FLNA FOXO1 FRS2 FYB GAB2 GAB3 GFAP GIT1 GJA1 GJB1 GNB2L1 GRB10 GRB2 GRIN2A GRIN2B GTF2I GUCY2C HDAC3 HLA-A HLA-B HNF1A HNF4G HNRNPK HRAS HSP90AA1 IGF1R IKBKB IKBKG IL6R INPPL1 INSR ITGB3 ITK JUP KAT2B KCNA5 KCNB1 KCNQ5 KDR KHDRBS1 KIFAP3 KIT LRP1 LYN MAP2 MAPK15 MAPK8IP3 MAPT MATK MED28 MET MICAL1 MPZL1 MST1R MUC1 MYLK NCOA6 ND2 NEDD4 NFKBIA NMT1 NOS2 NPHS1 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR3C1 NR3C2 NR5A2 P2RY2 PAK2 PDCD6IP PDE4D PDE6G PDGFRB PDPK1 PECAM1 PELP1 PGR PIK3R1 PKD1 PLCG1 PLD1 PLD2 PLSCR1 PPARA PPARD PPARGC1B PPP2R4 PRKACA PRKCA PRKCD PRKCE PRKCH PRKCI PRKCZ PRKD1 PTK2 PTK2B PTPN1 PTPN11 PTPN18 PTPN2 PTPN21 PTPN6 PTPRA PTPRE PXN RAF1 RARA RARB RARG RASA1 RET RGS16 RORB RPL10 RPS6KB1 RPS6KB2 RXRA RXRB SH2D3C SH3BP1 SH3PXD2A SHB SHC1 SKAP1 SKAP2 SLC9A2 SMARCB1 SMARCC1 SMARCE1 SNCA SNW1 SORBS1 SPTAN1 SRCIN1 SRF STAP2 STAT1 STAT3 STAT5A STAT5B STAT6 STUB1 SYK SYN1 TERT THRA THRB TIAM1 TNFRSF11A TNFRSF1A TNK2 TRAF1 TRAF3 TRAF6 TRAT1 TRIP10 TRIP6 TRPC6 TRPV4 TUB TXK TYRO3 USP8 VCL VDR VIL1 WAS WASL WBP11 WWOX YTHDC1 YWHAB YWHAE YWHAG YWHAH
Entrez ID 7132 6714
HPRD ID 01861 01819
Ensembl ID ENSG00000067182 ENSG00000197122
Uniprot IDs J9PH39 P19438 P12931
PDB IDs 1EXT 1FT4 1ICH 1NCF 1TNR 1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 4F59 4F5A 4F5B 4HXJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
casp3  cl  coincided  corpora  cyclic  disaggregation  estrous  extrinsic  fas  fasl  faslg  fos  ifng  ifngamma  jun  lutea  luteal  luteolysis  luteolytic  p4  pgf2alpha  postmortem  pregnancy  proportions  tnfa  tnfr2  viable 
acids  androgen  associate  auxiliary  beta1  box  cip  coactivator  coactivators  efficient  equivalent  glucocorticoid  gr  grip1  hormone  includes  lacks  lxxll  motifs  mutational  nid  nidaux  nr  nrs  p160  progesterone  recruit  retinoid  separable 
Tagcloud (Difference) ?
casp3  cl  coincided  corpora  cyclic  disaggregation  estrous  extrinsic  fas  fasl  faslg  fos  ifng  ifngamma  jun  lutea  luteal  luteolysis  luteolytic  p4  pgf2alpha  postmortem  pregnancy  proportions  tnfa  tnfr2  viable 
acids  androgen  associate  auxiliary  beta1  box  cip  coactivator  coactivators  efficient  equivalent  glucocorticoid  gr  grip1  hormone  includes  lacks  lxxll  motifs  mutational  nid  nidaux  nr  nrs  p160  progesterone  recruit  retinoid  separable 
Tagcloud (Intersection) ?