TNFRSF1A and MOAP1

Number of citations of the paper that reports this interaction (PMID 15949439)
34

Data Source:
HPRD (in vivo)

		TNFRSF1A	MOAP1
Gene Name		tumor necrosis factor receptor superfamily, member 1A	modulator of apoptosis 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway	Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)	Endometriosis ( 23472165)
Protein-Protein Interactions		60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	18 interactors: BAX BCL2 BCL2L1 CACNA1A CAMK2D CCDC85B DPPA2 FZR1 LATS1 MAGEH1 MBIP PNMA5 RASSF1 THOC1 TNFRSF10A TNFRSF1A UBC UBQLN4
Entrez ID		7132	64112
HPRD ID		01861	17580
Ensembl ID		ENSG00000067182	ENSG00000165943
Uniprot IDs		J9PH39 P19438	Q96BY2
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Extrinsic Apoptotic Signaling Pathway Cell Death Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Process Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Neuron Apoptotic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Process Release Of Cytochrome C From Mitochondria Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Nitrogen Utilization Regulation Of Neuron Death Regulation Of Mitochondrial Membrane Potential Regulation Of Phosphorylation Regulation Of Mitochondrial Membrane Permeability Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Membrane Permeability Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Regulation Of Protein Phosphorylation Regulation Of Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Abiotic Stimulus Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	adopted alignment atp6 classical cndp2 constructed csde1 csfv dnaja1 dnaja4 fancl fever gaining gopc hemorrhage hnrnph1 indications interactive library ncbi ns2 pnma1 regarded suvec swine switching tmed4 umbilical y2h
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable	adopted alignment atp6 classical cndp2 constructed csde1 csfv dnaja1 dnaja4 fancl fever gaining gopc hemorrhage hnrnph1 indications interactive library ncbi ns2 pnma1 regarded suvec swine switching tmed4 umbilical y2h
Tagcloud (Intersection) ?