PTK2 and SRC

Number of citations of the paper that reports this interaction (PMID 7997267)
296

Data Source:
HPRD (in vitro, in vivo)

		PTK2	SRC
Gene Name		protein tyrosine kinase 2	SRC proto-oncogene, non-receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Apical Plasma Membrane Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Late Endosome Cytosol Actin Filament Plasma Membrane Caveola Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding JUN Kinase Binding Protein Kinase Binding SH2 Domain Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity SH3/SH2 Adaptor Activity Protein Kinase C Binding Receptor Binding Insulin Receptor Binding Integrin Binding Protein Binding ATP Binding Protein C-terminus Binding Kinase Activity Enzyme Binding Heme Binding Estrogen Receptor Binding SH2 Domain Binding Ion Channel Binding Ephrin Receptor Binding Phosphoprotein Binding Hormone Receptor Binding Growth Factor Receptor Binding Scaffold Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Angiogenesis Vasculogenesis Neuron Migration Placenta Development Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cytoskeleton Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Embryo Development Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Regulation Of Rho GTPase Activity Regulation Of Cell Adhesion Mediated By Integrin Netrin-activated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Nucleus Localization Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Organ Growth Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Negative Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Synapse Assembly Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis	Cell Cycle Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development Blood Coagulation Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Mechanical Stimulus Response To Virus Response To Acidic PH Regulation Of Epithelial Cell Migration Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Smooth Muscle Cell Migration Viral Process Single Organismal Cell-cell Adhesion Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Platelet Activation Intracellular Estrogen Receptor Signaling Pathway Forebrain Development T Cell Costimulation Response To Nutrient Levels Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase B Activity Negative Regulation Of Protein Homooligomerization Cellular Response To Insulin Stimulus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Integrin Activation Adherens Junction Organization Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Osteoclast Development Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Transcytosis Innate Immune Response Regulation Of Bone Resorption Bone Resorption Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Oogenesis Positive Regulation Of Cytokine Secretion Progesterone Receptor Signaling Pathway Leukocyte Migration Response To Mineralocorticoid Response To Electrical Stimulus Regulation Of Cell Cycle Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitochondrial Depolarization Uterus Development Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cell Projection Assembly Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Peptide Hormone Stimulus Cellular Response To Progesterone Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Regulation Of Podosome Assembly Positive Regulation Of Podosome Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of DNA Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Caveolin-mediated Endocytosis
Pathways		Axon guidance DCC mediated attractive signaling Netrin mediated repulsion signals Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Programmed Cell Death EPH-Ephrin signaling NCAM signaling for neurite out-growth Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Signal regulatory protein (SIRP) family interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Signaling by VEGF Platelet activation, signaling and aggregation	Signaling by ERBB2
Drugs			Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5\'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN RU82129 PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric Acid RU81843 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib
Diseases
GWAS		Response to interferon beta therapy ( 21502966)	Retinopathy in non-diabetics ( 23393555)
Protein-Protein Interactions		104 interactors: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR F13A1 FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SHC1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TP53 TRIO TRIP6 TSC2 VCL YES1 ZNF331	279 interactors: ABL1 ACTN1 ADAM12 ADAM15 ADRB2 ADRB3 ADRBK1 AFAP1 AFAP1L2 AHR AKT1 ANKRD11 ANXA1 ANXA2 ANXA7 AR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP35 ARID1A ARNT ARR3 ASAP1 ATP2B4 AXL BCAR1 BCR BMX BRCA1 CA3 CARM1 CAV1 CAV2 CBL CBLC CCNA1 CD2AP CD33 CD36 CD44 CD46 CD59 CDC25C CDC37 CDCP1 CDH5 CDK5 CDKN1B CEACAM1 CEACAM3 CFL1 CHUK CLTC CNTNAP1 CORO7 CRMP1 CSK CTNNB1 CTNND1 CTTN DAB1 DAB2 DAG1 DAPP1 DDR2 DGKA DGKZ DLG4 DNM1 DNM2 DOK1 DOK2 DOK4 EFNA5 EFNB1 EFNB2 EFS EGFR EGLN1 ENO1 EP300 EPHA3 EPHA4 EPHB2 EPS8 ERBB2 ERBB3 ESR1 ESR2 ESRRA ESRRG ETS1 ETS2 EVL FARP2 FASLG FGR FHIT FLNA FOXO1 FRS2 FYB GAB2 GAB3 GFAP GIT1 GJA1 GJB1 GNB2L1 GRB10 GRB2 GRIN2A GRIN2B GTF2I GUCY2C HDAC3 HLA-A HLA-B HNF1A HNF4G HNRNPK HRAS HSP90AA1 IGF1R IKBKB IKBKG IL6R INPPL1 INSR ITGB3 ITK JUP KAT2B KCNA5 KCNB1 KCNQ5 KDR KHDRBS1 KIFAP3 KIT LRP1 LYN MAP2 MAPK15 MAPK8IP3 MAPT MATK MED28 MET MICAL1 MPZL1 MST1R MUC1 MYLK NCOA6 ND2 NEDD4 NFKBIA NMT1 NOS2 NPHS1 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR3C1 NR3C2 NR5A2 P2RY2 PAK2 PDCD6IP PDE4D PDE6G PDGFRB PDPK1 PECAM1 PELP1 PGR PIK3R1 PKD1 PLCG1 PLD1 PLD2 PLSCR1 PPARA PPARD PPARGC1B PPP2R4 PRKACA PRKCA PRKCD PRKCE PRKCH PRKCI PRKCZ PRKD1 PTK2 PTK2B PTPN1 PTPN11 PTPN18 PTPN2 PTPN21 PTPN6 PTPRA PTPRE PXN RAF1 RARA RARB RARG RASA1 RET RGS16 RORB RPL10 RPS6KB1 RPS6KB2 RXRA RXRB SH2D3C SH3BP1 SH3PXD2A SHB SHC1 SKAP1 SKAP2 SLC9A2 SMARCB1 SMARCC1 SMARCE1 SNCA SNW1 SORBS1 SPTAN1 SRCIN1 SRF STAP2 STAT1 STAT3 STAT5A STAT5B STAT6 STUB1 SYK SYN1 TERT THRA THRB TIAM1 TNFRSF11A TNFRSF1A TNK2 TRAF1 TRAF3 TRAF6 TRAT1 TRIP10 TRIP6 TRPC6 TRPV4 TUB TXK TYRO3 USP8 VCL VDR VIL1 WAS WASL WBP11 WWOX YTHDC1 YWHAB YWHAE YWHAG YWHAH
Entrez ID		5747	6714
HPRD ID		02859	01819
Ensembl ID		ENSG00000169398	ENSG00000197122
Uniprot IDs		E7ESA6 Q05397 Q59GM6 Q658W2	P12931
PDB IDs		1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO	1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 4F59 4F5A 4F5B 4HXJ
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Locomotion Cell Communication Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Immune System Process Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Cell Motility Chemotaxis Blood Coagulation Hemostasis Innate Immune Response Response To Growth Factor Response To Wounding Wound Healing Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Cell Adhesion Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Anatomical Structure Morphogenesis Leukocyte Migration Defense Response Regulation Of Body Fluid Levels Positive Regulation Of Protein Phosphorylation Response To Stress Axon Guidance Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Axon Development	Signaling Cell Communication Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Response To Organic Substance Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Anatomical Structure Development Developmental Process Positive Regulation Of Signal Transduction Response To Hormone System Development Cellular Response To Hormone Stimulus Multicellular Organismal Development Regulation Of Metabolic Process Anatomical Structure Morphogenesis Locomotion Regulation Of Cellular Component Organization Cell Differentiation Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Phosphorylation Regulation Of Immune System Process Intracellular Signal Transduction Regulation Of Cell Proliferation Intracellular Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Response To External Stimulus Innate Immune Response Immune System Process Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Immune Response Organ Development
Tagcloud ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid gr grip1 hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable
Tagcloud (Difference) ?		acta biochem brindle critchley davies fefpppptde flexneri icsa immunofluoresence microinjected microinjection nonmuscle oligoproline pdfpppppdl profilin reorganizes rocket sasakawa shigella submicromolar suzuki trailing unmasked unmasking unmasks usurping vasp vinc vinculin	acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid gr grip1 hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable
Tagcloud (Intersection) ?