IKBKB and SAMHD1

Number of citations of the paper that reports this interaction (PubMedID 37100289)
42

Data Source:
BioGRID (pull down, pull down)

		IKBKB	SAMHD1
Description		inhibitor of nuclear factor kappa B kinase subunit beta	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane Membrane CD40 Receptor Complex Membrane Raft	Nucleus Nucleoplasm Chromosome Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Transferrin Receptor Binding	Nucleotide Binding Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Catalytic Activity RNA Nuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Hydrolase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding Metal Ion Binding Deoxynucleoside Triphosphate Hydrolase Activity
	Biological Process	Protein Polyubiquitination Pattern Recognition Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Canonical NF-kappaB Signal Transduction Response To Virus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-serine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Protein Maturation Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly	Double-strand Break Repair Via Homologous Recombination Immune System Process DGTP Catabolic Process DNA Replication DNA Repair Immune Response DNA Damage Response Deoxyribonucleotide Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Innate Immune Response Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway DNA Strand Resection Involved In Replication Fork Processing
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes	Nucleotide catabolism Interferon alpha/beta signaling
Drugs		Mesalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
Diseases			Aicardi-Goutieres Syndrome (AGS)
GWAS			Caffeine consumption from coffee or tea ( 33287642) Height ( 28552196)
Interacting Genes		91 interacting genes: ACVR1 AKT1 AURKA BTRC CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 COPS5 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HMGCL HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH MYC NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR ROCK1 SAMHD1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB	15 interacting genes: ACTB APP ARAP3 CDK1 CHUK DYSF FAM13B FBXO25 FBXO7 IKBKB NONO SUMO2 TIRAP TRIM21 USP7
Entrez ID		3551	25939
HPRD ID		04462	08418
Ensembl ID		ENSG00000104365	ENSG00000101347
Uniprot IDs		A0A499FJS7 G3V105 O14920	A0A2R8YCS7 Q59H15 Q9Y3Z3
PDB IDs		3BRT 3BRV 4E3C 4KIK 8OMV	2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM 7A5Y 7LTT 7LU5 7S2Y 7UJN 8D94 8D9J 8GB1 8GB2 8QXJ 8QXK 8QXL 8QXM 8QXN 8QXO 8TDV 8TDW 9EC2
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Signal Transduction Protein Modification Process Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Non-canonical NF-kappaB Signal Transduction Protein Serine/threonine Kinase Activity Response To Stress Intracellular Signaling Cassette Macromolecule Metabolic Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Enzyme Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Modification Process Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Gene Expression Positive Regulation Of Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Protein Serine Kinase Activity	Regulation Of Innate Immune Response IkappaB Kinase Activity Post-translational Protein Modification Regulation Of Cellular Component Organization Innate Immune Response CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Transferrin Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response IkappaB Kinase Complex Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Positive Regulation Of Defense Response Defense Response To Other Organism Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Catabolic Process Regulation Of Circadian Rhythm Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Immune System Process Regulation Of Type I Interferon Production Protein Ubiquitination Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Immune System Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Response To Copper Ion Regulation Of Proteolysis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Immune Response
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