Wiki-Pi
About
Search
People
Updates
Search
IKBKB and TSC1
Number of citations of the paper that reports this interaction (PubMedID
17693255
)
0
Data Source:
BioGRID
(affinity chromatography technology, pull down)
IKBKB
TSC1
Description
inhibitor of nuclear factor kappa B kinase subunit beta
TSC complex subunit 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Nucleus
Cytoplasm
Lysosome
Lysosomal Membrane
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Protein-containing Complex
TSC1-TSC2 Complex
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Protein Folding Chaperone Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Protein Binding
Hsp70 Protein Binding
ATPase Inhibitor Activity
Protein Folding Chaperone
Protein-folding Chaperone Binding
Hsp90 Protein Binding
Biological Process
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Protein Folding
Potassium Ion Transport
Cell-matrix Adhesion
Nervous System Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Associative Learning
Adult Locomotory Behavior
Cellular Response To Starvation
Negative Regulation Of Macroautophagy
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATP-dependent Activity
Response To Insulin
Cellular Response To Decreased Oxygen Levels
TORC1 Signaling
Myelination
Memory T Cell Differentiation
Negative Regulation Of Cell Size
D-glucose Import
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
169 interacting genes:
ABI1
ACTN1
ACTN2
AKT1
ANKIB1
ANKRD24
ANKRD35
APPL2
AQP1
ARAF
ARID5A
ATN1
ATXN1
AURKA
AXIN1
BAG3
BCL11A
BECN1
BEND5
C1orf94
CALCOCO2
CASC3
CCDC120
CCDC88B
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CDR2
CHCHD2
CNIH1
CNTRL
CNTROB
COG6
CSTF2
CTNNB1
DACH2
DCTN2
DMRT3
DOK5
EIF3A
ENKD1
EZR
FAM110A
FAM222B
FBF1
FGFR4
FOXH1
FRS3
GCC1
GEMIN8
GFAP
GLIS2
GOLGA2
GPANK1
GPATCH1
HECW1
HGS
HNRNPM
HOMER3
HOOK2
HOXC8
HR
HSH2D
ICA1
IGFN1
IKBKB
KANSL2
KAT2A
KAZN
KDM1A
KIF1C
KIF5A
KLC1
KLC4
LATS2
LENG1
LMO2
LRSAM1
LUC7L
LZTS2
MAP2K5
MAPK14
MBIP
MBP
MSANTD3
MSN
MT-ND1
MYC
MYLIP
MYOZ3
NECAB2
NEFL
NF2
NINL
NKD2
NRBF2
PATL1
PATZ1
PHLDB1
PICK1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPFIA2
PPP1R18
PRMT6
RALYL
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
RUNDC3A
SAMD11
SAMD7
SAXO4
SCMH1
SEC31A
SELENOW
SERTAD1
SH2D2A
SHANK1
SHC3
SMG9
SORBS3
SOX4
SPAG5
SPAG8
SUOX
TANK
TBC1D7
TBX6
TCF7L2
TFAP2D
TFIP11
TLE5
TNS2
TRIM3
TRIOBP
TSC2
TSGA10IP
TSHZ3
USP2-AS1
VENTX
VEZF1
VGLL3
VIM
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF423
ZNF587
ZNF765
Entrez ID
3551
7248
HPRD ID
04462
05594
Ensembl ID
ENSG00000104365
ENSG00000165699
Uniprot IDs
A0A499FJS7
G3V105
O14920
A0A2R8Y5M3
A0A2R8Y5N2
A0A2R8Y5S3
A0A2R8Y6S1
A0A2R8YD74
A0A2R8YFV7
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
3BRT
3BRV
4E3C
4KIK
8OMV
4Z6Y
5EJC
7DL2
9C9I
9CE3
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
Cytoskeleton
Protein Domain Specific Binding
Regulation Of Primary Metabolic Process
Cytoplasm
Protein Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Spindle Pole
Microtubule-based Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of Biosynthetic Process
Protein Kinase Binding
Negative Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Cytoskeleton Organization
Organelle Organization
Negative Regulation Of Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Intracellular Transport
Cell Cycle G1/S Phase Transition
Mitotic Cell Cycle Phase Transition
Cytoskeletal Protein Binding
Cytosol
Regulation Of Protein Localization
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
Microtubule Cytoskeleton Organization Involved In Mitosis
MAPK Cascade
Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Early Endosome To Late Endosome Transport
Centrosome
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?