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IKBKB and FAF1
Number of citations of the paper that reports this interaction (PubMedID
17684021
)
0
Data Source:
BioGRID
(pull down, pull down)
IKBKB
FAF1
Description
inhibitor of nuclear factor kappa B kinase subunit beta
Fas associated factor 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Endomembrane System
CD95 Death-inducing Signaling Complex
VCP-NPL4-UFD1 AAA ATPase Complex
Perinuclear Region Of Cytoplasm
Ooplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Protein Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Protein Domain Specific Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
NF-kappaB Binding
Biological Process
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Apoptotic Process
Regulation Of Cell Adhesion
Fas Signaling Pathway
ERAD Pathway
Regulation Of Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of DNA Replication
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Drugs
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
GWAS
Appendicular lean mass (
33097823
)
Atrial fibrillation (
29290336
)
Blood urea nitrogen levels (
31152163
)
Body mass index and type 2 diabetes (pairwise) (
33619380
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Depression and alcohol dependence (
22064162
)
FEV1 (
30804560
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
25673412
34021172
)
Hippocampal tail volume (corrected for total hippocampal volume) (
30279459
)
Ischemic stroke (large artery atherosclerosis) (
26732560
)
Left ventricle wall thickness (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Lung function (FEV1/FVC) (
30804560
)
Lymphocyte percentage of white cells (
32888494
)
Male-pattern baldness (
28196072
)
Mean reticulocyte volume (
32888494
)
Multisite chronic pain (
33830993
31194737
)
Neutrophil percentage of white cells (
32888494
)
Pancreas fat (
34128465
)
Peak expiratory flow (
30804560
)
Postprandial triglyceride response (
32603185
)
Pulse pressure (
30578418
27841878
)
QRS duration (
21076409
30679814
)
Renal cell carcinoma (
28598434
)
Reticulocyte fraction of red cells (
32888494
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30297969
24509480
26818947
28869590
30718926
32499647
)
Ventricular ectopy (
29618737
)
Ventricular ectopy or supraventricular ectopy (pleiotropy) (
29618737
)
Interacting Genes
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
49 interacting genes:
AKT1
ANXA1
ANXA7
ASCC2
CASP8
CBS
CD40
CDC73
CDKN1A
CREBBP
CSNK2A1
CSNK2B
DNAJB11
FADD
FAF2
FAS
HSD17B10
HSPA1B
IGF2
IKBKB
ITGB1BP1
NEDD8
NGLY1
NLRP12
NLRP2
NLRP3
NLRP7
NR1H2
NR4A1
PRKN
RAP1A
RAP1B
RCC1
RELA
SIRT6
SKIL
SNIP1
SPOP
SUMO1
TAF1D
TK1
TNNT1
TSC22D1
UBC
UBE2I
UROD
WWP2
XIAP
YTHDF3
Entrez ID
3551
11124
HPRD ID
04462
05124
Ensembl ID
ENSG00000104365
ENSG00000185104
Uniprot IDs
A0A499FJS7
G3V105
O14920
Q9UNN5
PDB IDs
3BRT
3BRV
4E3C
4KIK
8OMV
1H8C
2DZM
2EC4
3E21
3QC8
3QCA
3QQ8
3QWZ
3QX1
3R3M
7FGM
7FGN
8KG2
Enriched GO Terms of Interacting Partners
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Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Proteolysis
Ubiquitin Protein Ligase Binding
Negative Regulation Of Biosynthetic Process
Cytosol
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Defense Response
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Lipid
Cytoplasm
Positive Regulation Of Protein Metabolic Process
Regulation Of Interleukin-1 Production
Regulation Of Innate Immune Response
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Identical Protein Binding
Regulation Of Immune System Process
Negative Regulation Of Signal Transduction
Nucleus
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
CD95 Death-inducing Signaling Complex
Positive Regulation Of Defense Response
Catabolic Process
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Tagcloud (Intersection)
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