IKBKB and TRAF3IP2

Number of citations of the paper that reports this interaction (PMID 10962033)
33

Data Source:
HPRD (in vivo)

		IKBKB	TRAF3IP2
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	TRAF3 interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Cellular_component
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding	Protein Binding
	Biological Process	B Cell Homeostasis Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Positive Regulation Of Sodium Ion Transport Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Serine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cation Channel Activity	B Cell Apoptotic Process Humoral Immune Response Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immunoglobulin Secretion
Pathways		Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival RIP-mediated NFkB activation via ZBP1 IRAK1 recruits IKK complex Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade TCR signaling Signaling by Interleukins Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling Cytokine Signaling in Immune system MyD88-independent cascade Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs		Mesalazine Sulfasalazine Auranofin Arsenic trioxide
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Psoriasis ( 20953188 20953190) Psoriatic arthritis ( 20953186)
Protein-Protein Interactions		78 interactors: ACVR1 AKT1 AURKA BCL10 CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 EIF2AK2 EIF2AK3 FAF1 FANCA FOXO3 HSP90AA1 HSP90AB1 HTT IKBKAP IKBKG IRS1 JUN MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 UBB YWHAB	18 interactors: CD40 CHUK FHL3 IKBKB IKBKG MAP3K7 MDFI MRPL28 RIMBP3 STK16 TBK1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIP6 UBE2V1
Entrez ID		3551	10758
HPRD ID		04462	06129
Ensembl ID		ENSG00000104365	ENSG00000056972
Uniprot IDs		O14920	O43734
PDB IDs		3BRT 3BRV 4E3C 4KIK
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Regulation Of Immune System Process Immune Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Defense Response Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cell Death Innate Immune Response-activating Signal Transduction Toll-like Receptor Signaling Pathway Death Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Innate Immune Response Regulation Of Innate Immune Response Programmed Cell Death Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Immune System Process Response To Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Response To Organic Substance Positive Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Innate Immune Response Negative Regulation Of Programmed Cell Death Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Phosphorylation	Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Innate Immune Response Regulation Of RNA Metabolic Process Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Defense Response Regulation Of Gene Expression
Tagcloud ?		abi analyse ctla4 episodes genotyped il4ra il8 map3k1 mbl2 nfkbia nfkbib polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing	acting aligned autoimmunity coevolution competitive disordered dn ds estimations evolved fall hosts interacting likelihood mammalian mammals nonsynonymous ordered outside pathogens plausible pressures purifying selection subject substitution synonymous terminus
Tagcloud (Difference) ?		abi analyse ctla4 episodes genotyped il4ra il8 map3k1 mbl2 nfkbia nfkbib polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing	acting aligned autoimmunity coevolution competitive disordered dn ds estimations evolved fall hosts interacting likelihood mammalian mammals nonsynonymous ordered outside pathogens plausible pressures purifying selection subject substitution synonymous terminus
Tagcloud (Intersection) ?