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IKBKB and FOXO3
Number of citations of the paper that reports this interaction (PubMedID
25241761
)
0
Data Source:
BioGRID
(imaging technique)
HPRD
(in vitro, in vivo)
IKBKB
FOXO3
Description
inhibitor of nuclear factor kappa B kinase subunit beta
forkhead box O3
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Matrix
Cytosol
Membrane
Protein-containing Complex
RNA Polymerase II Transcription Repressor Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Protein Kinase Binding
Chromatin DNA Binding
Mitochondrial Transcription Factor Activity
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Ovulation From Ovarian Follicle
Initiation Of Primordial Ovarian Follicle Growth
Antral Ovarian Follicle Growth
Oocyte Maturation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Mitochondrial Transcription
Regulation Of Translation
Apoptotic Process
Response To Xenobiotic Stimulus
Positive Regulation Of Autophagy
Positive Regulation Of Muscle Atrophy
DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Cell Migration
Response To Nutrient Levels
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Oxidative Stress
Cellular Response To Glucose Starvation
Glucose Homeostasis
Response To Starvation
Positive Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Brain Morphogenesis
Canonical Wnt Signaling Pathway
Response To Fatty Acid
Cellular Response To Glucose Stimulus
Cellular Response To Corticosterone Stimulus
Cellular Response To Hypoxia
Response To Dexamethasone
Negative Regulation Of Canonical Wnt Signaling Pathway
Neuronal Stem Cell Population Maintenance
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Response To Water-immersion Restraint Stress
Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Signaling by NODAL
AKT phosphorylates targets in the nucleus
Constitutive Signaling by AKT1 E17K in Cancer
MAPK6/MAPK4 signaling
Interleukin-4 and Interleukin-13 signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
RUNX3 regulates BCL2L11 (BIM) transcription
FLT3 Signaling
Regulation of localization of FOXO transcription factors
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Regulation of FOXO transcriptional activity by acetylation
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Mitochondrial unfolded protein response (UPRmt)
Drugs
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) (
32678081
)
Anxiety/tension (special factor of neuroticism) (
30867560
)
Appendicular lean mass (
33097823
)
Blood protein levels in cardiovascular risk (
28369058
)
BMI (adjusted for smoking behaviour) (
28443625
)
Body mass index (
28892062
28448500
25673413
)
Body mass index (joint analysis main effects and physical activity interaction) (
28448500
)
Body mass index in physically active individuals (
28448500
)
Brain morphology (MOSTest) (
32665545
)
Caffeine consumption from coffee or tea (
33287642
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Estimated glomerular filtration rate (
31152163
)
Extremely high intelligence (
29520040
)
General cognitive ability (
29844566
)
Height (
31562340
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
)
Insulin-like growth factors (
21216879
)
Intelligence (
28530673
)
Intelligence (MTAG) (
29326435
)
Lead levels (
26025379
)
Macular thickness (
30535121
)
Normalized brain volume (
19010793
)
Platelet distribution width (
27863252
32888494
)
Poor prognosis in Crohn's disease (
28067912
)
Prostate cancer (
23535732
)
Pulse pressure (
30224653
)
Reaction time (
29844566
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Schizophrenia (
28991256
30285260
)
Smoking status (ever vs never smokers) (
30643258
)
Subcortical volume (MOSTest) (
32665545
)
Thalamus volume (
34006833
)
Vigorous physical activity (
29899525
)
Waist circumference (
25673412
)
Weight (
28552196
)
Interacting Genes
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
27 interacting genes:
AKT1
ANAPC11
BTRC
CDK6
CDT1
CHUK
CREBBP
EP300
ERBIN
ESR1
FOXG1
IKBKB
MAPK1
MAPK6
MDM2
NR1H2
NR1H3
PTPA
SGK1
SIRT1
SMAD2
SMAD3
SMAD4
TERT
VDR
YWHAG
YWHAZ
Entrez ID
3551
2309
HPRD ID
04462
04061
Ensembl ID
ENSG00000104365
ENSG00000118689
Uniprot IDs
A0A499FJS7
G3V105
O14920
A0A856PRE8
O43524
PDB IDs
3BRT
3BRV
4E3C
4KIK
8OMV
2K86
2LQH
2LQI
2UZK
6MNL
7V9B
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
Intracellular Signal Transduction
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Immune Response
Regulation Of Gene Expression
Regulation Of Signal Transduction
Signal Transduction
Regulation Of Cell Differentiation
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Developmental Process
Regulation Of Macromolecule Metabolic Process
Transcription Coactivator Binding
Cellular Response To Nutrient Levels
Regulation Of Biological Quality
Regulation Of Multicellular Organismal Process
Regulation Of Protein Stability
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Immune System Process
Regulation Of Metabolic Process
Regulation Of Innate Immune Response
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Response To Oxygen Levels
Regulation Of Intracellular Signal Transduction
Response To Nutrient Levels
Regulation Of Defense Response
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Cell Communication
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