IKBKB and FOXO3

Number of citations of the paper that reports this interaction (PMID 15084260)
207

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		IKBKB	FOXO3
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	forkhead box O3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding Transcription Cofactor Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	B Cell Homeostasis Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Positive Regulation Of Sodium Ion Transport Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Serine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cation Channel Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Translation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Oxidative Stress Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival RIP-mediated NFkB activation via ZBP1 IRAK1 recruits IKK complex Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade TCR signaling Signaling by Interleukins Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling Cytokine Signaling in Immune system MyD88-independent cascade Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by NODAL Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Mesalazine Sulfasalazine Auranofin Arsenic trioxide
Diseases
GWAS			Insulin-like growth factors ( 21216879) Normalized brain volume ( 19010793) Prostate cancer ( 23535732)
Protein-Protein Interactions		78 interactors: ACVR1 AKT1 AURKA BCL10 CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 EIF2AK2 EIF2AK3 FAF1 FANCA FOXO3 HSP90AA1 HSP90AB1 HTT IKBKAP IKBKG IRS1 JUN MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 UBB YWHAB	24 interactors: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBB2IP ESR1 FOXG1 IKBKB MAPK1 MAPK6 NR1H2 NR1H3 SGK1 SIRT1 SMAD2 SMAD3 SMAD4 UBC VDR YWHAG YWHAZ
Entrez ID		3551	2309
HPRD ID		04462	04061
Ensembl ID		ENSG00000104365	ENSG00000118689
Uniprot IDs		O14920	B4DVZ6 O43524
PDB IDs		3BRT 3BRV 4E3C 4KIK	2K86 2LQH 2LQI 2UZK
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Regulation Of Immune System Process Immune Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Defense Response Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Metabolic Process Cell Death Innate Immune Response-activating Signal Transduction Toll-like Receptor Signaling Pathway Death Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Innate Immune Response Regulation Of Innate Immune Response Programmed Cell Death Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Immune System Process Response To Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Response To Organic Substance Positive Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Innate Immune Response Negative Regulation Of Programmed Cell Death Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Phosphorylation	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction DNA-templated Transcription, Initiation Signaling Response To Organic Substance Regulation Of Gene Expression Cellular Response To Stimulus Cell Communication Epithelium Development Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Mammary Gland Epithelium Development Intracellular Receptor Signaling Pathway Positive Regulation Of Transport Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Response To Organic Cyclic Compound Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stimulus Response To Hypoxia Apoptotic Process Mammary Gland Development Regulation Of Immune System Process Gland Development Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		abi analyse ctla4 episodes genotyped il4ra il8 map3k1 mbl2 nfkbia nfkbib polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation infiltrating let lungs mir mirna orchestrating participating pertaining poisoning ptgs2 runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Difference) ?		abi analyse ctla4 episodes genotyped il4ra il8 map3k1 mbl2 nfkbia nfkbib polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation infiltrating let lungs mir mirna orchestrating participating pertaining poisoning ptgs2 runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Intersection) ?