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IKBKB and PRKCB
Number of citations of the paper that reports this interaction (PubMedID
12070292
)
30
Data Source:
HPRD
(in vitro)
IKBKB
PRKCB
Description
inhibitor of nuclear factor kappa B kinase subunit beta
protein kinase C beta
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
Membrane
CD40 Receptor Complex
Membrane Raft
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Spectrin
Membrane
Calyx Of Held
Extracellular Exosome
Presynaptic Cytosol
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Transferrin Receptor Binding
Nucleotide Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Kinase C Binding
Calcium Channel Regulator Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Histone H3T6 Kinase Activity
Histone Binding
Metal Ion Binding
Nuclear Androgen Receptor Binding
Protein Serine Kinase Activity
Biological Process
Protein Polyubiquitination
Pattern Recognition Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Protein Maturation
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Adaptive Immune Response
Immune System Process
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Calcium Ion Transport
Intracellular Calcium Ion Homeostasis
Apoptotic Process
Mitotic Nuclear Membrane Disassembly
Signal Transduction
Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway
Regulation Of D-glucose Transmembrane Transport
Negative Regulation Of D-glucose Transmembrane Transport
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Insulin Secretion
Intracellular Signal Transduction
B Cell Activation
Lipoprotein Transport
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Insulin Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of Transport
Protein Kinase C Signaling
Cellular Response To Carbohydrate Stimulus
Presynaptic Modulation Of Chemical Synaptic Transmission
Regulation Of Synaptic Vesicle Exocytosis
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerization of the Nuclear Lamina
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Drugs
Mesalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Vitamin E
Tamoxifen
Phosphorylcolamine
Staurosporine
Dequalinium
Enzastaurin
Ellagic acid
Cholecystokinin
Benzoyl peroxide
alpha-Tocopherol succinate
D-alpha-Tocopherol acetate
Diseases
GWAS
Blood protein levels (
30072576
)
Bone mineral content (
31790847
)
Cadmium levels (
26025379
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Daytime nap (
33568662
)
Gut microbiota relative abundance (Dorea) (
33208821
)
Inflammatory bowel disease (
23128233
28067908
)
Lymphocyte count (
32888494
)
Post bronchodilator FEV1/FVC ratio in COPD (
26634245
)
Primary biliary cholangitis (
28062665
)
Sleep duration (
30531941
)
Systemic lupus erythematosus (
33272962
)
Ulcerative colitis (
28067908
)
Interacting Genes
91 interacting genes:
ACVR1
AKT1
AURKA
BTRC
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
COPS5
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HMGCL
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
MYC
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
ROCK1
SAMHD1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
88 interacting genes:
ACSL4
AFAP1
ANXA2
ANXA7
BLVRA
BMPR2
BTK
CARD11
CASR
CD5
CHAT
CHUK
CISH
CSF2RB
CYTH2
DAB2
DVL2
EGFR
EIF4E
EIF6
EP300
EPB41
FBXO7
GABRB2
GABRG2
GAP43
GCNT1
GJA1
GNA12
GNA13
GRIN1
GRIN2B
GRIN2D
GRK2
GRM5
GSK3A
GSK3B
H1-0
H1-1
H1-5
H3C1
HABP4
HSPA4
IBTK
IFNAR2
IKBKB
IKBKG
ITGB2
ITGB7
KIT
LIG1
LMNB1
LST1
MAPK6
MAPT
MARCKS
MBP
MKI67
NCF1
NRGN
NUMB
PA2G4
PDLIM5
PDLIM7
PDPK1
PEBP1
PPP1CA
PPP2CB
PTPA
PTPN11
RACK1
RASGRP3
RB1
RGS2
RIPK4
RRAD
SDC2
SPTAN1
STXBP1
SYT6
TERF1
TIAM1
TINF2
TOP2A
TRIM41
VTN
YWHAG
ZMYND8
Entrez ID
3551
5579
HPRD ID
04462
01499
Ensembl ID
ENSG00000104365
ENSG00000166501
Uniprot IDs
A0A499FJS7
G3V105
O14920
P05771
PDB IDs
3BRT
3BRV
4E3C
4KIK
8OMV
2I0E
8SG2
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Metabolic Process
Signal Transduction
Protein Modification Process
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Protein Serine/threonine Kinase Activity
Response To Stress
Intracellular Signaling Cassette
Macromolecule Metabolic Process
Protein Kinase Activity
Ubiquitin Protein Ligase Binding
Enzyme Binding
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein Modification Process
Protein Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Post-translational Protein Modification
Regulation Of Immune Response
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Protein Serine Kinase Activity
Regulation Of Signaling
Regulation Of Cellular Component Organization
Regulation Of Cell Communication
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Intracellular Signaling Cassette
Positive Regulation Of Cell Communication
Regulation Of Developmental Process
Cytoplasm
Plasma Membrane
Regulation Of Multicellular Organismal Process
Positive Regulation Of Signal Transduction
Regulation Of Biological Quality
Developmental Process
Regulation Of Postsynaptic Membrane Potential
Regulation Of Synaptic Plasticity
Regulation Of Intracellular Signal Transduction
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Cellular Component Organization
Focal Adhesion
Regulation Of Cell Projection Organization
Postsynapse
Regulation Of Membrane Potential
Cellular Response To Oxygen-containing Compound
Protein Kinase Binding
Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Differentiation
Cytosol
Regulation Of Protein Localization
Calmodulin Binding
Positive Regulation Of Transport
Regulation Of Transport
Regulation Of System Process
Regulation Of Cell Growth
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Protein-containing Complex Assembly
Neuronal Cell Body
Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Phospholipase Binding
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Development
Regulation Of DNA-binding Transcription Factor Activity
IkappaB Kinase Complex
Cellular Response To Interleukin-3
NMDA Glutamate Receptor Activity
Glutamate Binding
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