ITGA9 and NGF

Number of citations: 56 (PubMedID 18230652)
Data Source: BioGRID (pull down)

		ITGA9	NGF
Name		integrin subunit alpha 9	nerve growth factor
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Basal Plasma Membrane Cell Surface Membrane Integrin Alpha9-beta1 Complex	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytosol Synaptic Vesicle Axon Dendrite Endosome Lumen
	Molecular Function	Protein Binding Signaling Receptor Activity Metal Ion Binding Integrin Binding Involved In Cell-matrix Adhesion	Enzyme Inhibitor Activity Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Peptidase Inhibitor Activity Death Receptor Agonist Activity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Neutrophil Chemotaxis Negative Regulation Of Vasoconstriction Cell-cell Adhesion	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peripheral Nervous System Development Circadian Rhythm Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Nerve Development Neuron Projection Development Positive Regulation Of Protein Ubiquitination Nerve Growth Factor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Collateral Sprouting Axon Extension Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1	PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs		None	Clenbuterol RI 624 Polaprezinc Fasinumab Oleandrin
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	None
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Anti-human herpes virus 6 IE1A IgG seropositivity ( 33204752 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Mortality in sepsis ( 27639821 ) Nasopharyngeal carcinoma ( 19478819 ) Phospholipid levels (plasma) ( 22359512 ) Platelet count ( 32888494 ) PR interval ( 23139255 ) Pulse pressure ( 30224653 30578418 ) Response to antidepressants (symptom improvement) ( 29160301 ) Systolic blood pressure ( 30578418 )	Coronary artery disease ( 33020668 ) Diastolic blood pressure ( 27841878 ) Dysmenorrheic pain ( 27454463 ) Dysmenorrheic pain severity ( 29855537 ) Menstruation quality of life impact (dysmenorrhea) ( 29855537 ) Migraine ( 27182965 27322543 ) Migraine without aura ( 27322543 ) Obstetric antiphospholipid syndrome ( 28424481 ) Pain medicine use during menstruation ( 29855537 ) Pediatric non-alcoholic fatty liver disease activity score ( 23535911 ) Red blood cell count ( 32888494 ) Schizophrenia ( 30285260 ) Systolic blood pressure ( 27841878 )
Novel Interactors		1 novel interactors: GPX1	None recorded
Interacting Genes		6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD	11 interacting genes: A2M CRYAB ITGA9 ITGB1 LRP1 MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		3680	4803
HPRD ID		04910	08874
Ensembl ID		ENSG00000144668	ENSG00000134259
Uniprot IDs		Q13797 Q8N6H6	A0A346FYQ1 P01138
PDB IDs		Not available	1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7 6YW8
GO Terms Enriched among Interactors		Angiogenesis Endothelial Cell Migration Regulation Of Collateral Sprouting Enzyme-linked Receptor Protein Signaling Pathway Myoblast Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Fibroblast Proliferation Protein Tyrosine Kinase Binding Axon Extension Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vascular Endothelial Growth Factor Receptor 3 Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Growth Muscle Cell Differentiation Striated Muscle Cell Differentiation Response To Vitamin Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Neuron Projection Extension Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Transforming Growth Factor Beta Receptor Signaling Pathway Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Regulation Of Neurogenesis Regulation Of Nervous System Development Integrin Alpha9-beta1 Complex Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Neuron Apoptotic Process Regulation Of Cellular Component Organization Developmental Cell Growth Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Positive Regulation Of Neuron Maturation Diamine N-acetyltransferase Activity Regulation Of Estradiol Secretion Growth Factor Activity	Nerve Growth Factor Binding Cell Surface Integrin Alpha9-beta1 Complex Nerve Growth Factor Receptor Activity Neurotrophin Binding Integrin Binding Involved In Cell-matrix Adhesion Cellular Response To Amyloid-beta Synaptic Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse Modulation Of Chemical Synaptic Transmission Response To Amyloid-beta Signaling Receptor Activity Amyloid-beta Binding Negative Regulation Of Vasoconstriction Enzyme-linked Receptor Protein Signaling Pathway Nerve Growth Factor Signaling Pathway Protease Binding Neurotrophin TRK Receptor Signaling Pathway Apolipoprotein Binding Detection Of Temperature Stimulus Dendritic Spine Response To Temperature Stimulus System Process Integrin Complex Neurotrophin Signaling Pathway Plasma Membrane Myoblast Differentiation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Receptor Complex Regulation Of Cell Motility Regulation Of Locomotion Extracellular Matrix Disassembly Nerve Development Extracellular Matrix Organization Extracellular Structure Organization Vascular Process In Circulatory System Myoblast Fate Specification Learning Or Memory Coreceptor Activity Integrin Alpha7-beta1 Complex Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Antibacterial Peptide Secretion Neurotrophin P75 Receptor Binding Neurotensin Receptor Activity, Non-G Protein-coupled Cell Surface Receptor Signaling Pathway Endosome Membrane Platelet Alpha Granule Lumen