PLD3 and SMCO4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLD3	SMCO4
Description		phospholipase D family member 3	single-pass membrane protein with coiled-coil domains 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endosome Membrane Endomembrane System Membrane Early Endosome Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome	Membrane
	Molecular Function	Catalytic Activity Nuclease Activity Exonuclease Activity Phospholipase D Activity Protein Binding Hydrolase Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity	Protein Binding
	Biological Process	Immune System Process DNA Metabolic Process Lipid Metabolic Process Inflammatory Response Myotube Differentiation Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Synthesis of PG Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)	Adult body size ( 32376654) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		13 interacting genes: ANXA7 BCL2L1 CNIH3 GPR35 HGS NFKB1 OGT OPRM1 SMCO4 SOX4 SPP1 STK11 TK1	62 interacting genes: AQP6 ARL13B BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35H1 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1
Entrez ID		23646	56935
HPRD ID		07148	17008
Ensembl ID		ENSG00000105223	ENSG00000166002
Uniprot IDs		Q8IV08	Q9NRQ5
PDB IDs		8Q1K 8Q1X 8S86 8V5T
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Autophagy Negative Regulation Of Developmental Process Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Process Regulation Of Neurotransmitter Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Alkaloid Mitochondrial Membrane Regulation Of Signal Transduction Apoptotic Process In Bone Marrow Cell Positive Regulation Of Transport Regulation Of Signaling Receptor Activity Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Cell Growth Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macroautophagy Vacuole-isolation Membrane Contact Site Response To Ketone Regulation Of Protein Localization Negative Regulation Of Growth Synapse Regulation Of Cellular Response To Stress Protein Localization To Lysosome Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Reproductive Process Regulation Of Canonical Wnt Signaling Pathway NF-kappaB P50/p65 Complex Regulation Of Secretion By Cell Cellular Response To Glucose Stimulus Positive Regulation Of Estradiol Secretion Thymidine Kinase Activity C-terminal Protein Lipidation Regulation Of Growth Mitochondrion Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Positive Regulation Of Lipid Transport Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex	Membrane Protein Binding
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