KIF5A and BACH1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		KIF5A	BACH1
Description		kinesin family member 5A	BTB domain and CNC homolog 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Ciliary Rootlet Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Axon Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Kinesin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Heme Binding Ligand-modulated Transcription Factor Activity
	Biological Process	Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 18794853 24449572) Smoking initiation (ever regular vs never regular) ( 30679032)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Creatine kinase levels ( 29403010) Haemorrhoidal disease ( 33888516) Pancreatic cancer ( 22158540) Selective IgA deficiency ( 27723758) Visceral fat ( 22589738)
Interacting Genes		24 interacting genes: BACH1 CREBBP DSCAM DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 MAPK10 NCOA2 NDEL1 NRIP1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSC1 TSG101 YAP1	18 interacting genes: ANAPC5 ATF2 BATF2 BRCC3 CFTR DDIT3 DYNLL1 HMMR KIF5A MAFB MAFK NR1D1 PATZ1 RBCK1 RPS27A TCF4 USP7 WAC
Entrez ID		3798	571
HPRD ID		09108	04127
Ensembl ID		ENSG00000155980	ENSG00000156273
Uniprot IDs		J3KNA1 Q12840	O14867
PDB IDs		4UXT 4UXY 4UY0	2IHC 8S7D 8UA3 8UA6 8UAH 8UBT 8UBU 8UBV 9GP5 9GR9 9GRA
Enriched GO Terms of Interacting Partners?		Cytoplasm Ciliary Rootlet Kinesin Complex Microtubule Neuron Projection Axo-dendritic Transport Postsynaptic Cytosol Intracellular Signal Transduction Establishment Of Vesicle Localization Microtubule Binding Vesicle Localization Transcription Coregulator Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Axon Cytoplasm Transport Along Microtubule Axonal Transport Anterograde Dendritic Transport Protein Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Transcription Corepressor Activity Microtubule-based Transport Dendritic Transport Positive Regulation Of GTPase Activity Proline-rich Region Binding Plus-end-directed Microtubule Motor Activity Regulation Of Modification Of Synaptic Structure Retrograde Axonal Transport Positive Regulation Of Cell Communication Rhythmic Process Positive Regulation Of Signaling Signal Transduction Establishment Of Organelle Localization Positive Regulation Of Hydrolase Activity Cell Projection Organization Transcription Coactivator Activity Dendrite Cytoplasm Positive Regulation Of Cellular Component Biogenesis Hippo Signaling Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Intracellular Signaling Cassette Regulation Of Phosphorus Metabolic Process Nervous System Development Centrosome Localization Regulation Of GTPase Activity Response To Progesterone Regulation Of Cellular Component Organization Synaptic Vesicle Transport Regulation Of Protein Localization	RNA Polymerase II Transcription Regulator Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Integrated Stress Response Signaling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of DNA-binding Transcription Factor Activity CAMP Response Element Binding Protein Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Leucine Zipper Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Response To Nutrient Levels DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA Damage Checkpoint Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Post-translational Protein Modification Nucleus Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Mononuclear Cell Differentiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II T Cell Differentiation Signal Transduction In Response To DNA Damage Macromolecule Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Leukocyte Differentiation Proteolysis Involved In Protein Catabolic Process Response To Stress Regulation Of Insulin Secretion Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Abducens Nucleus Development Hypoglossal Nucleus Development DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
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