KIF5A and TSG101

Number of citations of the paper that reports this interaction (PMID 15256501)
44

Data Source:
BioGRID (two hybrid)

		KIF5A	TSG101
Gene Name		kinesin family member 5A	tumor susceptibility 101
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Perinuclear Region Of Cytoplasm	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity	DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding
	Biological Process	Microtubule-based Movement Synaptic Transmission Axon Guidance Blood Coagulation Protein Localization Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoskeleton-dependent Intracellular Transport	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 18794853)
Protein-Protein Interactions		16 interactors: DTNB EXOC1 ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 NCOA2 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TSG101 YAP1	69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D
Entrez ID		3798	7251
HPRD ID		09108	03229
Ensembl ID		ENSG00000155980	ENSG00000074319
Uniprot IDs		J3KNA1 Q12840	Q99816
PDB IDs			1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE
Enriched GO Terms of Interacting Partners?		System Development Cytoskeleton-dependent Intracellular Transport Multicellular Organismal Development Anatomical Structure Development Regulation Of Signaling Nervous System Development Cellular Localization Developmental Process Regulation Of Potassium Ion Transport Fetal Process Involved In Parturition Regulation Of Signal Transduction Establishment Of Localization In Cell Microtubule-based Movement Negative Regulation Of Melanin Biosynthetic Process Skeletal Muscle Cell Proliferation Stress Granule Disassembly Neuron Projection Development Keratinocyte Differentiation Movement Of Cell Or Subcellular Component Axon Guidance Brain-derived Neurotrophic Factor Receptor Signaling Pathway Generation Of Neurons Positive Regulation Of Ras GTPase Activity Neuron Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Neuron Projection Development Cell Differentiation Neurogenesis Positive Regulation Of CAMP-dependent Protein Kinase Activity Microtubule-based Transport Epidermal Cell Differentiation Cell Morphogenesis Negative Regulation Of Cell Projection Organization Regulation Of Extracellular Vesicular Exosome Assembly Plus-end-directed Vesicle Transport Along Microtubule Response To Cortisol Thymidine Metabolic Process Response To Ionizing Radiation Cell Development Axonogenesis Regulation Of Ras GTPase Activity Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Epithelial Cell Differentiation Neuron Differentiation Intracellular Signal Transduction Cell Projection Organization Deoxyribonucleoside Monophosphate Biosynthetic Process Response To CGMP	Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator
Tagcloud ?		adaptor autonomous axonal cargo charcot cmt contexts degenerate exacerbates hsp hyperexcitability incompletely kbp kif1b kifs kinesin marie motors nonmitochondrial paraplegia polyneuropathy redundant redundantly reminiscent spastic strikingly vertebrate	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Difference) ?		adaptor autonomous axonal cargo charcot cmt contexts degenerate exacerbates hsp hyperexcitability incompletely kbp kif1b kifs kinesin marie motors nonmitochondrial paraplegia polyneuropathy redundant redundantly reminiscent spastic strikingly vertebrate	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Intersection) ?