KIF5A and KIF5B

Number of citations of the paper that reports this interaction (PMID 10964943)
44

Data Source:
HPRD (in vivo)

		KIF5A	KIF5B
Gene Name		kinesin family member 5A	kinesin family member 5B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Microtubule Organizing Center Kinesin Complex Microtubule Membrane Endocytic Vesicle Vesicle Ciliary Rootlet Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	Microtubule-based Movement Synaptic Transmission Axon Guidance Blood Coagulation Protein Localization Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoskeleton-dependent Intracellular Transport	Microtubule-based Movement Cytoplasm Organization Axon Guidance Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Cellular Protein Metabolic Process Vesicle Transport Along Microtubule Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 18794853)	Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		16 interactors: DTNB EXOC1 ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 NCOA2 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TSG101 YAP1	23 interactors: APC CDC5L DTNB GSK3B KIF5A KLC3 KTN1 NCOA2 NDRG1 PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A
Entrez ID		3798	3799
HPRD ID		09108	07214
Ensembl ID		ENSG00000155980	ENSG00000170759
Uniprot IDs		J3KNA1 Q12840	P33176 Q6P164
PDB IDs			1BG2 1MKJ 2P4N 4HNA
Enriched GO Terms of Interacting Partners?		System Development Cytoskeleton-dependent Intracellular Transport Multicellular Organismal Development Anatomical Structure Development Regulation Of Signaling Nervous System Development Cellular Localization Developmental Process Regulation Of Potassium Ion Transport Fetal Process Involved In Parturition Regulation Of Signal Transduction Establishment Of Localization In Cell Microtubule-based Movement Negative Regulation Of Melanin Biosynthetic Process Skeletal Muscle Cell Proliferation Stress Granule Disassembly Neuron Projection Development Keratinocyte Differentiation Movement Of Cell Or Subcellular Component Axon Guidance Brain-derived Neurotrophic Factor Receptor Signaling Pathway Generation Of Neurons Positive Regulation Of Ras GTPase Activity Neuron Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Neuron Projection Development Cell Differentiation Neurogenesis Positive Regulation Of CAMP-dependent Protein Kinase Activity Microtubule-based Transport Epidermal Cell Differentiation Cell Morphogenesis Negative Regulation Of Cell Projection Organization Regulation Of Extracellular Vesicular Exosome Assembly Plus-end-directed Vesicle Transport Along Microtubule Response To Cortisol Thymidine Metabolic Process Response To Ionizing Radiation Cell Development Axonogenesis Regulation Of Ras GTPase Activity Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Epithelial Cell Differentiation Neuron Differentiation Intracellular Signal Transduction Cell Projection Organization Deoxyribonucleoside Monophosphate Biosynthetic Process Response To CGMP	Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Protein Transport Establishment Of Protein Localization Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Development Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Apoptotic Process Mast Cell Activation Programmed Cell Death Regulation Of Intracellular Transport Intracellular Signal Transduction Cell Death Cellular Localization Death Regulation Of Apoptotic Process Intracellular Transport Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Transmission Neurogenesis Positive Regulation Of Signal Transduction Histamine Secretion By Mast Cell Signaling Regulation Of Organelle Organization Nervous System Development Cell Communication Transport Regulation Of Cellular Component Organization Synaptic Vesicle Priming Histamine Secretion
Tagcloud ?		adaptor autonomous axonal cargo charcot cmt contexts degenerate exacerbates hsp hyperexcitability incompletely kbp kif1b kifs kinesin marie motors nonmitochondrial paraplegia polyneuropathy redundant redundantly reminiscent spastic strikingly vertebrate	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		adaptor autonomous axonal cargo charcot cmt contexts degenerate exacerbates hsp hyperexcitability incompletely kbp kif1b kifs kinesin marie motors nonmitochondrial paraplegia polyneuropathy redundant redundantly reminiscent spastic strikingly vertebrate	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?