KIF5A and RAPGEF2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		KIF5A	RAPGEF2
Description		kinesin family member 5A	Rap guanine nucleotide exchange factor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Ciliary Rootlet Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Axon Cytoplasm	Cytoplasm Endosome Late Endosome Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Protein-containing Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Kinesin Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding WW Domain Binding Phosphatidic Acid Binding
	Biological Process	Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport	MAPK Cascade Blood Vessel Development Neuron Migration Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Cell Differentiation Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Rap Protein Signal Transduction Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Positive Regulation Of Microvillus Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration
Pathways		MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	RAF/MAP kinase cascade
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 18794853 24449572) Smoking initiation (ever regular vs never regular) ( 30679032)	Dietary fat liking ( 32516399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Molybdenum levels ( 26025379) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		24 interacting genes: BACH1 CREBBP DSCAM DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 MAPK10 NCOA2 NDEL1 NRIP1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSC1 TSG101 YAP1	14 interacting genes: CTNNB1 DYRK1A HSPA1A IL16 KIF5A KIF5B MAGI2 MOB4 MT-ATP8 NEDD4 RALGDS RAP1A RAP2B SPP1
Entrez ID		3798	9693
HPRD ID		09108	19358
Ensembl ID		ENSG00000155980	ENSG00000109756
Uniprot IDs		J3KNA1 Q12840	A0A994J7S7 Q9Y4G8
PDB IDs		4UXT 4UXY 4UY0	6QDT
Enriched GO Terms of Interacting Partners?		Cytoplasm Ciliary Rootlet Kinesin Complex Microtubule Neuron Projection Axo-dendritic Transport Postsynaptic Cytosol Intracellular Signal Transduction Establishment Of Vesicle Localization Microtubule Binding Vesicle Localization Transcription Coregulator Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Axon Cytoplasm Transport Along Microtubule Axonal Transport Anterograde Dendritic Transport Protein Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Transcription Corepressor Activity Microtubule-based Transport Dendritic Transport Positive Regulation Of GTPase Activity Proline-rich Region Binding Plus-end-directed Microtubule Motor Activity Regulation Of Modification Of Synaptic Structure Retrograde Axonal Transport Positive Regulation Of Cell Communication Rhythmic Process Positive Regulation Of Signaling Signal Transduction Establishment Of Organelle Localization Positive Regulation Of Hydrolase Activity Cell Projection Organization Transcription Coactivator Activity Dendrite Cytoplasm Positive Regulation Of Cellular Component Biogenesis Hippo Signaling Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Intracellular Signaling Cassette Regulation Of Phosphorus Metabolic Process Nervous System Development Centrosome Localization Regulation Of GTPase Activity Response To Progesterone Regulation Of Cellular Component Organization Synaptic Vesicle Transport Regulation Of Protein Localization	Perinuclear Region Of Cytoplasm Postsynaptic Cytosol Synaptic Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport Regulation Of Transport Ciliary Rootlet Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Dense Core Granule Cytoskeletal Transport Rap Protein Signal Transduction Anterograde Dendritic Transport Protein Transport Along Microtubule Nerve Growth Factor Signaling Pathway Nervous System Development Establishment Of Vesicle Localization Dendritic Transport Plus-end-directed Microtubule Motor Activity Bicellular Tight Junction Vesicle Localization Regulation Of Inclusion Body Assembly Retrograde Axonal Transport Secretory Granule Localization Neuron Projection Regulation Of Metal Ion Transport Epithelial Cell Development Apicolateral Plasma Membrane Disordered Domain Specific Binding Dendrite Cytoplasm Intracellular Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Neuron Projection Development Positive Regulation Of Transport Vesicle Regulation Of Cell Communication Regulation Of Signaling Establishment Of Endothelial Barrier Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Endothelial Cell Development Positive Regulation Of RNA Splicing Cellular Response To Nerve Growth Factor Stimulus Vesicle Transport Along Microtubule Kinesin Complex Anterograde Axonal Transport Response To Nerve Growth Factor Cytoskeleton
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?